Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene.[5][6]
Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain.[7] The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.
^ abcGRCh38: Ensembl release 89: ENSG00000070019 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000042638 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Guanylatecyclase2C, also known as guanylyl cyclase C (GC-C), intestinal guanylatecyclase, guanylatecyclase-C receptor, or the heat-stable enterotoxin...
Guanylatecyclase (EC 4.6.1.2, also known as guanyl cyclase, guanylyl cyclase, or GC; systematic name GTP diphosphate-lyase (cyclizing; 3′,5′-cyclic-GMP-forming))...
effects in others include diarrhea. It is an oligopeptide agonist of guanylatecyclase2C and remains in the GI tract after it is taken by mouth. It was approved...
of trachea, stomach and gall bladder 63 Guanylin GN Peptide gut guanylatecyclase2C (heat stable enterotoxin receptor) regulates electrolyte and water transport...
consists of a monoclonal antibody (indusatumab) that targets the enzyme guanylatecyclase2C which is present in some cancers, linked to an average of three to...
the EAL domain, the GGDEF domain, the protein phosphatase 2C-like domain, the guanylatecyclase domain, or the response regulatory domain. In its most common...
Ileus Caused by Mutations in GUCY2C, Encoding the CFTR-Activating GuanylateCyclase2C". American Journal of Human Genetics. 90 (5): 893–899. doi:10.1016/j...
Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylatecyclase receptors, which results in increased levels of cGMP, leading to smooth...
Global Information
