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Guaifenesin protocol is an unapproved treatment for fibromyalgia suggested in the 1990s by R. Paul St. Amand. The protocol involves three parts: titrating the guaifenesin dosage, avoiding salicylates, and following a low-carbohydrate diet if the patient is hypoglycemic. Guaifenesin has not been approved by the FDA for the treatment of fibromyalgia, and the protocol has not been shown to be effective in clinical trials. Despite the lack of clinical efficacy, the protocol has been adopted by many due to anecdotal evidence of success.[1][2][3]
^Bennett, R.; deGarmo, P.; Clark, S. (1996). "1112. A 1 year double blind, placebo controlled study of guaifensin in fibromyalgia". Program Overview. American College College of Rheumatology 60th National Scientific Meeting; Association of Rheumatology Health Professionals 31st Scientific Meeting. p. S212. doi:10.1002/art.1780391402.
^Bennett, R.M.; Clark, S.R; De Garmo, P. "Report on a randomized, prospective, 12 month study to compare the efficacy of guaifesin versus placebo in the management of fibromyalgia". myalgia.com. Fibromyalgia Information Foundation.
^"Is one placebo better than another? -- The guaifenesin story". Consumer Alerts. fmnetnews.com. Coping Resources. Fibromyalgia Network. Archived from the original on 2011-10-23.
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