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Chemical compound
Glucosepane is a lysine-arginine protein cross-linking product and advanced glycation end product (AGE) derived from D-glucose.[1] It is an irreversible, covalent cross-link product that has been found to make intermolecular and intramolecular cross-links in the collagen of the extracellular matrix (ECM) and crystallin of the eyes.[2] Covalent protein cross-links irreversibly link proteins together in the ECM of tissues. Glucosepane is present in human tissues at levels 10 to 1000 times higher than any other cross-linking AGE, and is currently considered to be the most important cross-linking AGE.[3]
^Lederer, M.O., Bühler, H.P. (1999). "Cross-linking of proteins by maillard processes - Characterization and detection of a lysine-arginine cross-link derived from D-glucose". Bioorganic and Medicinal Chemistry. 7 (6): 1081–1088. doi:10.1016/S0968-0896(99)00040-1. PMID 10428377.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Sell, D. R., Biemel, K. M., Reihl, O., Lederer, M. O., Strauch, C. M., & Monnier, V. M. (2005). "Glucosepane is a major protein cross-link of the senescent human extracellular matrix: Relationship with diabetes". Journal of Biological Chemistry. 280 (13): 12310–12315. doi:10.1074/jbc.M500733200. PMID 15677467.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Monnier, V. M., Mustata, G. T., Biemel, K. L., Reihl, O., Lederer, M. O., Zhenyu, D.; et al. (2005). "Cross-linking of the extracellular matrix by the maillard reaction in aging and diabetes: An update on "a puzzle nearing resolution"". Annals of the New York Academy of Sciences. 1043: 533–544. Bibcode:2005NYASA1043..533M. doi:10.1196/annals.1333.061. PMID 16037276. S2CID 27507321.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Glucosepane is a lysine-arginine protein cross-linking product and advanced glycation end product (AGE) derived from D-glucose. It is an irreversible...
evidence that it is effective against the most prevalent crosslink: glucosepane. Alteon said that it had selected ALT-711 as its lead AGE-breaker based...
been used to identify a bond path network of hydrogen bonds between glucosepane and nearby water molecules. In QTAIM the energy increase on decreasing...
16 June 2021. "Revel Pharmaceuticals Finally Seed Funded to Develop Glucosepane Cross-Link Breakers". Fight Aging!. 2020-01-07. SENS Research Foundation...