The Gewald reaction is an organic reaction involving the condensation of a ketone (or aldehyde when R2 = H) with a α-cyanoester in the presence of elemental sulfur and base to give a poly-substituted 2-amino-thiophene.[1][2]
The Gewald reaction
The reaction is named after the German chemist Karl Gewald (born 1930).[3][4][5]
^Gewald, K.; Schinke, E.; Böttcher, H. Ber.1966, 99, 94-100.
^Sabnis, R. W. Sulfur Rep.1994, 16, 1-17. (Review)
^John A. Joule, Keith Mills: Heterocyclic Chemistry, John Wiley & Sons, 5. Auflage (2010), p. 340, ISBN 978-1-4051-3300-5.
^Bradford P. Mundy, Michael G. Ellerd, Frank G. Favaloro, Jr.: Name Reactions and Reagents in Organic Synthesis, John Wiley & Sons, 2. Auflage (2005) p. 306, ISBN 0-471-22854-0.
^Christopher Hume: Applications of Multicomponent Reactions in Drug Discovery – Lead Generation to Process Development, p. 311−341, see p. 332−334, In Jieping Zhu, Huges Bienaymé: Multicomponent Reactions, Wiles-VCH Verlag, 2005, ISBN 978-3-527-30806-4.
The Gewaldreaction is an organic reaction involving the condensation of a ketone (or aldehyde when R2 = H) with a α-cyanoester in the presence of elemental...
strong base in this reaction would induce self-condensation of the aldehyde or ketone. The Hantzsch pyridine synthesis, the Gewaldreaction and the Feist–Benary...
preparation of CS gas: Malononitrile is a suitable starting material for the Gewaldreaction, where the nitrile condenses with a ketone or aldehyde in the presence...
similarly using Lawesson's reagent as the sulfidizing agent, or via the Gewaldreaction, which involves the condensation of two esters in the presence of elemental...
authors list (link). Gewald, K.; Spies, H.; Mayer, R. (1970). "Zur Reaktion von Enaminen mit Schwefel und Cyanamid" [On the Reaction of Enamines with Sulfur...
Z.; Mack, James (8 April 2014). "A Solvent-Free, One-Step, One-Pot GewaldReaction for Alkyl-aryl Ketones via Mechanochemistry". Applied Sciences. 4 (2):...
University of Halle-Wittenberg, and Karl Gewald, who is best known for the development of the Gewaldreaction and his work in the field of thiophenes and...
id=28&tx_ttnews%5Btt_news%5D=54620&no_cache=1, captured on August 20, 2011 Gewald, Jan-Bart, "Herereo Heroes: A Socio-Political History of the Herero of Namibia...
ISSN 1381-1312. Gewald, J. B. (2000). "Colonization, Genocide and Resurgence: The Herero of Namibia, 1890–1933". In Bollig, M.; Gewald, J. B. (eds.). People...
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