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Genetic heterogeneity information


Genetic heterogeneity occurs through the production of single or similar phenotypes through different genetic mechanisms. There are two types of genetic heterogeneity: allelic heterogeneity, which occurs when a similar phenotype is produced by different alleles within the same gene; and locus heterogeneity, which occurs when a similar phenotype is produced by mutations at different loci.[1]

  1. ^ Scriver, Charles (January 27, 2006). "Allelic and Locus Heterogeneity". Encyclopedia of Life Sciences. John Wiley & Sons. doi:10.1038/npg.els.0005481. ISBN 978-0470016176.

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Genetic heterogeneity

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different genetic mechanisms. There are two types of genetic heterogeneity: allelic heterogeneity, which occurs when a similar phenotype is produced by...

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Tumour heterogeneity

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tumours (inter-tumour heterogeneity) and within tumours (intra-tumour heterogeneity). A minimal level of intra-tumour heterogeneity is a simple consequence...

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Genetic studies on Arabs

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of Omanis, Emiratis, and Bahrainis. The study confirmed the high genetic heterogeneity among Arabs, especially those of the Arabian Peninsula. The most...

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Homogeneity and heterogeneity

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Various disciplines understand heterogeneity, or being heterogeneous, in different ways. Environmental heterogeneity (EH) is a hypernym for different...

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Locus heterogeneity

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Locus heterogeneity and allelic heterogeneity are the two components of genetic heterogeneity. Locus heterogeneity may have major implications for a...

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Genetic counseling

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"Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum". American Journal of Human Genetics. 65...

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Chandman culture

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culture, while retainers of comparatively lower status had high genetic heterogeneity, representing influxes from the many parts of the Xiongnu Empire...

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Uyuk culture

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empire and describe patterns of genetic diversity related to social status. Overall, we find that genetic heterogeneity is highest among lower-status individuals...

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Negrito

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East Asian peoples and Oceanian peoples, as well as displaying genetic heterogeneity. The Negritos form the indigenous population of Southeast Asia,...

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Xiongnu

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empire and describe patterns of genetic diversity related to social status. Overall, we find that genetic heterogeneity is highest among lower-status individuals...

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Osteogenesis imperfecta

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is a group of genetic disorders, all of which cause bone fragility. OI has high genetic heterogeneity, that is, many different genetic mutations lead...

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Tuareg people

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ISBN 978-0-8161-1808-3. Arauna, Lara R; Comas, David (15 September 2017). "Genetic Heterogeneity between Berbers and Arabs". eLS: 1–7. doi:10.1002/9780470015902...

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Somatic evolution in cancer

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clonal expansions and genetic heterogeneity within many different types of neoplasms. There are multiple levels of genetic heterogeneity associated with cancer...

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Ancient Northeast Asian

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empire and describe patterns of genetic diversity related to social status. Overall, we find that genetic heterogeneity is highest among lower-status individuals...

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Turkic peoples

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Age Yellow River farmer ancestry. A 2020 study also found "high genetic heterogeneity and diversity during the Türkic and Uyghur periods" in the early...

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Genetic studies on Moroccans

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populations. Berbers themselves enclose genetically diverse groups and have a high degree of genetic heterogeneity. The human leukocyte antigen HLA DNA data...

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Fur people

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October 2009.[full citation needed] John S. H. Tay; N. Saha (1988). "Genetic Heterogeneity Among the Negroid and Arab Tribes of the Sudan". American Journal...

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served as a migratory route and an agent of genetic flow which contributed to present-day heterogeneity in Egypt. A study by Arredi et al., which analyzed...

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Fraser syndrome

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excluded linkage to both the FRAS1 and FREM2 genes, indicating genetic heterogeneity.[citation needed] In 5 families with Fraser syndrome, McGregor et...

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Neoplasm

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Schmitt MW, Prindle MJ, Loeb LA (September 2012). "Implications of genetic heterogeneity in cancer". Ann. N. Y. Acad. Sci. 1267 (1): 110–6. Bibcode:2012NYASA1267...

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Syrians

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Arnaiz-Villena, Antonio; Hattab, Lasmar; Hmida, Slama (9 March 2018). "The Genetic Heterogeneity of Arab Populations as Inferred from HLA Genes". PLOS ONE. 13 (3):...

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Autosomal dominant polycystic kidney disease

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intrafamilial variability, which can be explained to a large extent by its genetic heterogeneity and modifier genes. It is also the most common of the inherited...

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Allelic heterogeneity

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different mutations in the β-globin gene. Allelic heterogeneity should not be confused with locus heterogeneity in which a mutation at a different gene causes...

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Sicilians

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Arnaiz-Villena, Antonio; Hattab, Lasmar; Hmida, Slama (9 March 2018). "The genetic heterogeneity of Arab populations as inferred from HLA genes". PLOS ONE. 13 (3):...

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Genetic history of North Africa

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genetic studies on North African populations agree with a limited correlation between genetics and geography, showing a high population heterogeneity...

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