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Gemifloxacin information


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Gemifloxacin
Clinical data
AHFS/Drugs.comMonograph
MedlinePlusa604014
Pregnancy
category
  • C
Routes of
administration		Oral/IV under development
ATC code
  • J01MA15 (WHO)
Legal status
Legal status
  • US: WARNING[1]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability71%
Protein binding60–70%
MetabolismLimited metabolism by the liver to minor metabolites
ExcretionFeces (61%); urine (36%)
Identifiers
IUPAC name
  • 7-[(4Z)-3-(Aminomethyl)-4-methoxyimino-pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo- 1,8-naphthyridine-3-carboxylic acid
CAS Number
  • 175463-14-6 checkY
PubChem CID
  • 9571107
DrugBank
  • DB01155 checkY
ChemSpider
  • 7845573 checkY
UNII
  • OKR68Y0E4T
KEGG
  • D08012 ☒N
ChEBI
  • CHEBI:101853 checkY
ChEMBL
  • ChEMBL430 checkY
CompTox Dashboard (EPA)
  • DTXSID3048495 Edit this at Wikidata
Chemical and physical data
FormulaC18H20FN5O4
Molar mass389.387 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • Fc2c(nc1N(/C=C(/C(=O)O)C(=O)c1c2)C3CC3)N4C/C(=N\OC)C(C4)CN
InChI
  • InChI=1S/C18H20FN5O4/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27)/b22-14+ checkY
  • Key:ZRCVYEYHRGVLOC-HYARGMPZSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Gemifloxacin mesylate is an oral broad-spectrum quinolone antibacterial agent used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. Vansen Pharma Inc. has licensed the active ingredient from LG Life Sciences of Korea.

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

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