In organic chemistry, the Ganem oxidation is a name reaction that allows for the preparation of carbonyls from primary or secondary alkyl halides with the use of trialkylamine N-oxides, such as N-methylmorpholine N-oxide or trimethylamine N-oxide.[1]
^Godfrey, Alexander G.; Ganem, Bruce (1990-05-30). "Ready oxidation of halides to aldehydes using trimethylamine N-oxide in dimethylsulfoxide". Tetrahedron Letters. 31 (34): 4825–4826. doi:10.1016/S0040-4039(00)97742-6.
Kornblum oxidation protocol, which was originally developed using dimethyl sulfoxide or pyridine-N-oxide as the nucleophile. The Ganemoxidation has been...
substrates: various sulfoxides (e.g. the Swern oxidation), or amine oxides (e.g., the Ganemoxidation). Sterically-hindered nitroxyls (i.e., TEMPO) can...
pyridine-N-oxide or similar reagents rather than DMSO. The Ganemoxidation built on this latter modification, expanding on the use of various N-oxide reagents...
also referred to as the Corey-Suggs reagent, is widely used for the oxidation of alcohols to corresponding ketones and aldehydes. PCC has several advantages...
229. Bibcode:1977JChEd..54Q.229H. doi:10.1021/ed054p229.1. Doheny Jr AJ, Ganem B (1980). "Purple benzene revisited". Journal of Chemical Education. 57...
Removed by acid, hydrogenolysis, or oxidation – commonly with DDQ. p,m‑Dimethoxybenzyl ether — Removed via oxidation with DDQ or ceric ammonium chloride...
(22): 5287–5298. doi:10.1016/S0040-4020(01)87705-X. McKittrick, Brian A.; Ganem, Bruce (1985). "Syn-stereoselective epoxidation of allylic ethers using...
of Oxidation also rests upon the assumption that ligand binding confers protection to proteins from manners of degradation, this time from oxidation of...
one part of the molecule to another. In other words, they catalyze the oxidation of one part of the molecule and the concurrent reduction of another part...
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