GRAMD1C information

GRAMD1C
Identifiers
Aliases	GRAMD1C, GRAM domain containing 1C, Aster-C
External IDs	MGI: 2443024; HomoloGene: 9726; GeneCards: GRAMD1C; OMA:GRAMD1C - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	113,947,174 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	43,883,708 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; bronchial epithelial cell; ; epithelium of nasopharynx; ; germinal epithelium; ; sperm; ; right uterine tube; ; kidney tubule; ; palpebral conjunctiva; ; body of pancreas; ; renal medulla;
	Top expressed in
	olfactory epithelium; ; spermatocyte; ; otolith organ; ; utricle; ; spermatid; ; seminiferous tubule; ; zygote; ; primary oocyte; ; vestibular sensory epithelium; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; cholesterol binding; cholesterol transfer activity; lipid binding;
Cellular component	membrane; integral component of membrane; endoplasmic reticulum membrane; plasma membrane; endoplasmic reticulum-plasma membrane contact site; endoplasmic reticulum;
Biological process	cholesterol transport; cellular response to cholesterol; intermembrane sterol transfer; lipid transport;
	Sources:Amigo / QuickGO
Orthologs
	54762
	207798
	ENSG00000178075
	ENSMUSG00000036292
	Q8IYS0
	Q8CI52
	NM_001172105; NM_017577
	NM_001172107; NM_153528; NM_001359085
	NP_001165576; NP_060047
NP_001165578; NP_705756; NP_001346014; NP_001395263; NP_001395264;
	NP_001395265
	Wikidata
View/Edit Human	View/Edit Mouse

GRAM domain containing 1C also known as Aster-C is a cholesterol transport protein that is encoded by the GRAMD1C gene.^[5]^[6] It contains a transmembrane region, a GRAM domain and a VASt domain. It is anchored to the endoplasmic reticulum through its transmembrane domain.^[7]

GRAMD1C has four paralogs: GRAMD1B and GRAMD1A and two without VASt domains, GRAMD2A and GRAMD2B. Homologs of GramD proteins (Lam/Ltc proteins) are found in yeast.^[7]

The protein is expressed in the liver and testes.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178075 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036292 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GRAM domain containing 1C". Retrieved 2018-10-17.
^ "UniProtKB - Q8IYS0 (ASTRC_HUMAN)". Retrieved March 6, 2020.
^ ^a ^b ^c Naito T, Saheki Y (August 2021). "GRAMD1-mediated accessible cholesterol sensing and transport". Biochim Biophys Acta Mol Cell Biol Lipids. 1866 (8): 158957. doi:10.1016/j.bbalip.2021.158957. PMID 33932585. S2CID 233477388.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178075 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036292 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GRAM domain containing 1C". Retrieved 2018-10-17.

[6] "UniProtKB - Q8IYS0 (ASTRC_HUMAN)". Retrieved March 6, 2020.

[Naito-7] Naito T, Saheki Y (August 2021). "GRAMD1-mediated accessible cholesterol sensing and transport". Biochim Biophys Acta Mol Cell Biol Lipids. 1866 (8): 158957. doi:10.1016/j.bbalip.2021.158957. PMID 33932585. S2CID 233477388.

GRAMD1C information

and 4 Related for: GRAMD1C information

GRAMD1C

GRAM domain

Gram domain containing 1a

Gram domain containing 1b