GFPT1 information

GFPT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2V4M, 2ZJ3, 2ZJ4
Identifiers
Aliases	GFPT1, CMSTA1, GFA, GFAT, GFAT 1, GFAT1, GFAT1m, GFPT, GFPT1L, MSLG, CMS12, glutamine--fructose-6-phosphate transaminase 1
External IDs	OMIM: 138292; MGI: 95698; HomoloGene: 68220; GeneCards: GFPT1; OMA:GFPT1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	69,387,250 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	87,069,179 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; islet of Langerhans; ; rectum; ; stromal cell of endometrium; ; corpus epididymis; ; jejunal mucosa; ; Achilles tendon; ; palpebral conjunctiva; ; duodenum; ; bronchial epithelial cell;
	Top expressed in
	left colon; ; parotid gland; ; submandibular gland; ; conjunctival fornix; ; Paneth cell; ; epithelium of stomach; ; condyle; ; fossa; ; seminal vesicula; ; lacrimal gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; transaminase activity; carbohydrate derivative binding; glutamine-fructose-6-phosphate transaminase (isomerizing) activity;
Cellular component	cytosol; extracellular exosome;
Biological process	rhythmic process; circadian regulation of gene expression; IRE1-mediated unfolded protein response; glutamine metabolic process; UDP-N-acetylglucosamine biosynthetic process; energy reserve metabolic process; carbohydrate derivative biosynthetic process; fructose 6-phosphate metabolic process; carbohydrate derivative metabolic process; UDP-N-acetylglucosamine metabolic process; protein N-linked glycosylation;
	Sources:Amigo / QuickGO
Orthologs
	2673
	14583
	ENSG00000198380
	ENSMUSG00000029992
	Q06210
	P47856
	NM_002056; NM_001244710
	NM_013528
	NP_001231639; NP_002047
	NP_038556
	Wikidata
View/Edit Human	View/Edit Mouse

Glucosamine—fructose-6-phosphate aminotransferase isomerizing 1 is an enzyme that in humans is encoded by the GFPT1 gene.^[5]^[6]

Glutamine-fructose-6-phosphate transaminase 1 is the first and rate-limiting enzyme of the hexosamine pathway. GFAT controls the flux of glucose into the hexosamine pathway and catalyzes the formation of glucosamine 6-phosphate.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198380 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029992 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McKnight GL, Mudri SL, Mathewes SL, Traxinger RR, Marshall S, Sheppard PO, O'Hara PJ (Jan 1993). "Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase". J Biol Chem. 267 (35): 25208–12. doi:10.1016/S0021-9258(19)74026-5. PMID 1460020.
^ ^a ^b "Entrez Gene: GFPT1 glutamine-fructose-6-phosphate transaminase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198380 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029992 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1460020-5] McKnight GL, Mudri SL, Mathewes SL, Traxinger RR, Marshall S, Sheppard PO, O'Hara PJ (Jan 1993). "Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase". J Biol Chem. 267 (35): 25208–12. doi:10.1016/S0021-9258(19)74026-5. PMID 1460020.

[entrez-6] "Entrez Gene: GFPT1 glutamine-fructose-6-phosphate transaminase 1".

GFPT1 information

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GFPT1

Chromosome 2

Stress granule

SKIV2L2

SKIV2L