GPCR-Autoproteolsis INducing (GAIN) domain, rat latrophilin 4DLQ mediates autocatalytic cleavage of adhesion GPCRs
The GAIN domain (G-protein-coupled receptor (GPCR) autoproteolysis-inducing domain) is a protein domain found in a number of cell surface receptors, including adhesion-GPCRs and polycystic kidney disease proteins PKD1 and PKD2. The domain is involved in the self-cleavage of these transmembrane receptors, and has been shown to be crucial for their function [citation needed].[1] Point mutations within the GAIN domain of PKD1 and GPR56 are known to cause polycystic kidney disease and polymicrogyria, respectively.[2][3][4]
^Trudel, Marie; Yao, Qin; Qian, Feng (2016-01-21). "The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease". Cells. 5 (1): 3. doi:10.3390/cells5010003. ISSN 2073-4409. PMC 4810088. PMID 26805887.
^Araç, D; Boucard, AA; Bolliger, MF; Nguyen, J; Soltis, SM; Südhof, TC; Brunger, AT (Feb 14, 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
^Lin, HH; Chang, GW; Davies, JQ; Stacey, M; Harris, J; Gordon, S (Jul 23, 2004). "Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif". The Journal of Biological Chemistry. 279 (30): 31823–32. doi:10.1074/jbc.M402974200. PMID 15150276.
^Chang, GW; Stacey, M; Kwakkenbos, MJ; Hamann, J; Gordon, S; Lin, HH (Jul 17, 2003). "Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif". FEBS Letters. 547 (1–3): 145–50. doi:10.1016/S0014-5793(03)00695-1. PMID 12860403. S2CID 23329033.
The GAINdomain (G-protein-coupled receptor (GPCR) autoproteolysis-inducing domain) is a protein domain found in a number of cell surface receptors, including...
laser emission Gain (projection screens) Information gain in decision trees, in mathematics and computer science GAINdomain, a protein domain Learning rate...
authoritative name servers of the queried domain. With this function implemented in the name server, user applications gain efficiency in design and operation...
A domain name registrar is a company that manages the reservation of Internet domain names. A domain name registrar must be accredited by a generic top-level...
curves is the loop gain, β×AOL. Loop Gain and its Effects on Analog Circuit Performance v t e This article incorporates public domain material from Federal...
variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. This gene encodes a member...
device. Insertion gain is usually expressed in dB. "Insertion Loss / Return Loss". 19 April 2017. This article incorporates public domain material from Federal...
layer to gain access to the data and behavior of the model. In the Unified Modeling Language (UML), a class diagram is used to represent the domain model...
electronics, control systems engineering, and statistics, the frequency domain refers to the analysis of mathematical functions or signals with respect...
These exceptions thus allowed Satsuma to gain even more power and wealth relative to the majority of other domains. Though arguably opposed to the shogunate...
connection due to the support for a certification authority which is gained when a domain is added to a network, and as a result, smart cards and digital certificates...
variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. GRCh38: Ensembl release...
modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. EMR1 expression in human is restricted to...
form a domain hack became well established. On Friday, May 3, 2002, icio.us was registered to create del.icio.us. Delicious would later gain control...
"Google mirror". It was created by All Too Flat "for fun", which started to gain popularity in 2002. elgooG found practical use in mainland China after the...
{\displaystyle \rho \leq 2} [b/2D or b/s/Hz], i.e. the domain of binary signaling), the effective coding gain γ e f f ( A ) {\displaystyle \gamma _{\mathrm {eff}...
variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. GRCh38: Ensembl release...
In abstract algebra, a Dedekind domain or Dedekind ring, named after Richard Dedekind, is an integral domain in which every nonzero proper ideal factors...
machine-learning community has many different strategies to attempt to gain better domain adaptation. An algorithm trained on newswires might have to adapt...
variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. GPR124 has been shown to...
variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. GRCh38: Ensembl release...