Global InformationFuroquinoline alkaloid information
Furoquinoline alkaloids are a group of alkaloids with simple structure. Distribution of this group of alkaloids is essentially limited to plant family Rutaceae. The simplest member of this group is dictamnine and most widespread member is skimmianine.[1]
A furoquinoline alkaloid, dictamnine, is very common within the family Rutaceae. It is the main alkaloid in the roots of Dictamnus albus and responsible for the mutagenicity of the drug derived from crude extracts.[2] Dictamnine was also reported to be a phototoxic and photomutagenic compound.[3] It participates in the severe skin phototoxicity of the plant.[4] Another furoquinoline alkaloid, skimmianine, has strong antiacetylcholinesterase activity.[5]
- ^ Cordell, Geoffrey A. (1981). Introduction to Alkaloids: A Biogenetic Approach. John Wiley & Sons. pp. 243–252. ISBN 0-471-03478-9.
- ^ Mizuta, M; Kanamori, H (1985). "Mutagenic activities of dictamnine and gamma-fagarine from dictamni radicis cortex (Rutaceae)". Mutation Research. 144 (4): 221–5. doi:10.1016/0165-7992(85)90054-5. PMID 4069140.
- ^ Schimmer, O; Kühne, I (1991). "Furoquinoline alkaloids as photosensitizers in Chlamydomonas reinhardtii". Mutation Research. 249 (1): 105–10. doi:10.1016/0027-5107(91)90136-c. PMID 2067526.
- ^ Schempp, CM; Sonntag, M; Schöpf, E; Simon, JC (1996). "Dermatitis bullosa striata pratensis caused by Dictamnus albus L. (burning bush)". Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete. 47 (9): 708–10. doi:10.1007/s001050050494. PMID 8999028. S2CID 23601334.
- ^ Yang, Zhong-duo; Zhang, Dong-bo; Ren, Jin; Yang, Ming-jun (2011). "Skimmianine, a furoquinoline alkaloid from Zanthoxylum nitidum as a potential acetylcholinesterase inhibitor". Medicinal Chemistry Research. 21 (6): 722–725. doi:10.1007/s00044-011-9581-9. S2CID 14113860.