Finafloxacin information

Finafloxacin
Clinical data
Trade names	Xtoro
Routes of; administration	otic, oral, intavenous
ATC code	None;
Legal status
Legal status	CA: ℞-only; US: ℞-only;
Pharmacokinetic data
Elimination half-life	10 hours
Identifiers
	IUPAC name 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid;
CAS Number	209342-40-5;
PubChem CID	11567473;
ChemSpider	9742243;
UNII	D26OSN9Q4R;
KEGG	D10575 ;
ChEBI	CHEBI:85176 ;
ChEMBL	ChEMBL1908370;
CompTox Dashboard (EPA)	DTXSID10175096 ;
Chemical and physical data
Formula	C20H19FN4O4
Molar mass	398.394 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C1=CN(C2CC2)c3c(C1=O)cc(F)c(c3C#N)N4C[C@H]5[C@H](C4)NCCO5;
	InChI InChI=1S/C20H19FN4O4/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28)/t15-,16-/m0/s1; Key:FYMHQCNFKNMJAV-HOTGVXAUSA-N;

Finafloxacin (Xtoro) is a fluoroquinolone antibiotic. In the United States, it is approved by the Food and Drug Administration to treat acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus.^[2]

^ "Health Canada New Drug Authorizations: 2016 Highlights". Health Canada. 14 March 2017. Retrieved 7 April 2024.
^ "FDA approves Xtoro to treat swimmer's ear". Food and Drug Administration. December 17, 2014.

[1] "Health Canada New Drug Authorizations: 2016 Highlights". Health Canada. 14 March 2017. Retrieved 7 April 2024.

[2] "FDA approves Xtoro to treat swimmer's ear". Food and Drug Administration. December 17, 2014.

Finafloxacin information

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Clinical data

Trade names	Xtoro
Routes of administration	otic, oral, intavenous
ATC code	None
Legal status
Legal status	CA: ℞-only^[1] US: ℞-only
Pharmacokinetic data
Elimination half-life	10 hours
Identifiers
IUPAC name 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
CAS Number	209342-40-5
PubChem CID	11567473
ChemSpider	9742243
UNII	D26OSN9Q4R
KEGG	D10575^Y
ChEBI	CHEBI:85176^Y
ChEMBL	ChEMBL1908370
CompTox Dashboard (EPA)	DTXSID10175096
Chemical and physical data
Formula	C₂₀H₁₉FN₄O₄
Molar mass	398.394 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(O)C1=CN(C2CC2)c3c(C1=O)cc(F)c(c3C#N)N4C[C@H]5[C@H](C4)NCCO5
InChI InChI=1S/C20H19FN4O4/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28)/t15-,16-/m0/s1 Key:FYMHQCNFKNMJAV-HOTGVXAUSA-N