Global InformationFences and pickets model of plasma membrane structure information
The fences and pickets model of plasma membrane is a concept of cell membrane structure suggesting that the fluid plasma membrane is compartmentalized by actin-based membrane-skeleton "fences" and anchored transmembrane protein "pickets". This model differs from older cell membrane structure concepts such as the Singer-Nicolson fluid mosaic model and the Saffman-Delbrück two-dimensional continuum fluid model that view the membrane as more or less homogeneous. The fences and pickets model was proposed to explain observations of molecular traffic made due to recent advances in single molecule tracking techniques.[1]
- ^ Kusumi A, Nakada C, Ritchie K, Murase K, Suzuki K, Murakoshi H, Kasai RS, Kondo J, Fujiwara T (2005). "Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules". Annual Review of Biophysics and Biomolecular Structure. 34: 351–78. doi:10.1146/annurev.biophys.34.040204.144637. PMID 15869394.