Crystallographic structure of the Fel d 1 dimer, the primary allergen present in cat saliva [1]
Identifiers
Symbol
Feld-I_B
Pfam
PF09252
Pfam clan
CL0370
InterPro
IPR015332
SCOP2
1puo / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Fel d 1 is a secretoglobin protein complex that, in cats, is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes.[2][3]
Among cats, Fel d 1 is produced largely in their saliva and by the sebaceous glands located in their skin. It is the primary allergen present on cats and kittens.[1][4] The function of the protein for cats is unknown, but it causes an IgG or IgE reaction in sensitive humans (either as an allergic or asthmatic response).
^ abPDB: 1PUO; Kaiser L, Grönlund H, Sandalova T, Ljunggren HG, van Hage-Hamsten M, Achour A, Schneider G (September 2003). "The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family". The Journal of Biological Chemistry. 278 (39): 37730–5. doi:10.1074/jbc.M304740200. PMID 12851385.
^Morgenstern JP, Griffith IJ, Brauer AW, Rogers BL, Bond JF, Chapman MD, Kuo MC (November 1991). "Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 88 (21): 9690–4. Bibcode:1991PNAS...88.9690M. doi:10.1073/pnas.88.21.9690. PMC 52784. PMID 1946388.
^Griffith IJ, Craig S, Pollock J, Yu XB, Morgenstern JP, Rogers BL (April 1992). "Expression and genomic structure of the genes encoding FdI, the major allergen from the domestic cat". Gene. 113 (2): 263–8. doi:10.1016/0378-1119(92)90405-E. PMID 1572548.
^Dabrowski AJ, Van der Brempt X, Soler M, Seguret N, Lucciani P, Charpin D, Vervloet D (October 1990). "Cat skin as an important source of Fel d I allergen". The Journal of Allergy and Clinical Immunology. 86 (4 Pt 1): 462–5. doi:10.1016/S0091-6749(05)80200-3. PMID 2229808.
hypoallergenic than any other cat. Most human cat allergies are caused by Feld1. Allerca (and earlier, Geneticas) scientists tried to delete or disable...
There is speculation that the Russian Blue produces less glycoprotein Feld1, one source of cat allergies. The thicker coat may also trap more of the...
cats are not the result of hair length, but from a glycoprotein known as Feld1, produced in the sebaceous glands of the skin, saliva, and urine. Most...
allergic reaction. The proteins that cause allergies (mainly Feld1 in cats and Can f 1 in dogs) are found not only in the animals' fur or hair but also...
recognise an allergen (typically this is a protein, such as dust mite Der p 1, cat Feld1, grass or ragweed pollen, food protein, etc.) has a unique long-lived...
hypoallergenic properties primarily attributed to lower levels of the Feld1 protein. The Neva Masquerade carries the same colourpoint gene (c.904G>A...
(Leopardus tigrinus): All known examples are infertile. The feline protein Feld1 has been fused with the human protein FcGamma1, in what has been described...
the slow loris: sequence similarity of prosimian skin gland protein and Feld1 cat allergen" (PDF). Naturwissenschaften. 90 (2): 60–62. Bibcode:2003NW...
of antibodies against Feld 4 than against Feld1, another prominent cat allergen. Likewise, Equ c 1 (Equus caballus allergen 1; Q95182) is the protein...
of an allergy to proteins in the saliva of pets, such as Feld1 in cat allergy and Can f 1 in dog allergy. Cases of serious infection following the licking...
Feldspar (/ˈfɛl(d)ˌspɑːr/ FEL(D)-spar; sometimes spelled felspar) is a group of rock-forming aluminium tectosilicate minerals, also containing other cations...
2013). "Allergens as immunomodulatory proteins: the cat dander protein Feld1 enhances TLR activation by lipid ligands". Journal of Immunology. 191 (4):...
the original D 567 and D 568 were ultimately published under the same D number as two versions of the same sonata. Deutsch catalogue Nos. 1–1C 2–12 13–37...
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hypoallergenic. Allergies to cats are triggered by a protein called Fel d1, not cat hair itself. Fel d1 is a protein primarily found in cat saliva and sebaceous...
the Fate of the Jedi series. Roan Fel Deposed Galactic Emperor in the Star Wars: Legacy series. Baron Soontir Fel Elite Imperial starfighter pilot in...
vol. 13, no. 1-2, pp. 59-60, 1957 Solecki, R. S., "The 1956 season at Shanidar.", Sumer, vol. 13, no. 1-2, pp. 165-171, 1957 Stewart, T. D., "First views...
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