proteasome-mediated ubiquitin-dependent protein catabolic process
protein ubiquitination
regulation of centrosome duplication
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
protein polyubiquitination
regulation of mitotic nuclear division
post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
54461
30839
Ensembl
ENSG00000159069
ENSMUSG00000015095
UniProt
Q969U6
Q9QXW2
RefSeq (mRNA)
NM_018998 NM_178225 NM_178226
NM_013908 NM_001356407 NM_001356408
RefSeq (protein)
NP_061871
NP_038936 NP_001343336 NP_001343337
Location (UCSC)
Chr 9: 136.94 – 136.94 Mb
Chr 2: 25.39 – 25.4 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.[5]
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated Messenger RNA decay candidates, hence not represented.[5] Well established targets of FBXW5 include TSC2[6] and SEC23B.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000159069 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000015095 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene. This gene encodes a member of the F-box protein family, members of...
the brain. Documented PLK4 substrates include STIL, GCP6, Hand1, Ect2, FBXW5, and itself (via autophosphorylation). Autophosphorylation of PLK4 results...