Etynodiol diacetate, or ethynodiol diacetate, sold under the brand name Ovulen among others, is a progestin medication which is used in birth control pills.[4][5][6] The medication is available only in combination with an estrogen.[7] It is taken by mouth.[8]
Etynodiol diacetate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.[9][10] It has weak androgenic and estrogenic activity and no other important hormonal activity.[11][12][13] The medication is a prodrug of norethisterone in the body, with etynodiol occurring as an intermediate.[9][10][14]
Etynodiol, a related compound, was discovered in 1954, and etynodiol diacetate was introduced for medical use in 1965.[15][16] The combination ethynodiol with mestranol (Ovulen) was approved for medical use in the United States in 1966.[17] The combination ethinylestradiol with ethynodiol (Demulen) was approved for medical use in the United States in 1970.[18]
In 2021, the combination with ethinylestradiol was the 276th most commonly prescribed medication in the United States, with more than 800,000 prescriptions.[19][20]
^Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, et al. (December 2003). "Classification and pharmacology of progestins". Maturitas. 46 (Suppl 1): S7–S16. doi:10.1016/j.maturitas.2003.09.014. PMID 14670641.
^"Zovia 1/35- ethynodiol diacetate and ethinyl estradiol tablets kit". Archived from the original on 28 September 2022. Retrieved 20 January 2024.
^"Kelnor 1/35- ethynodiol diacetate and ethinyl estradiol kit". Archived from the original on 29 March 2023. Retrieved 20 January 2024.
^Shoupe D, Haseltine FP (6 December 2012). Contraception. Springer Science & Business Media. pp. 21–. ISBN 978-1-4612-2730-4.
^Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 522–. ISBN 978-1-4757-2085-3.
^Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 422. ISBN 978-3-88763-075-1. Retrieved 30 May 2012.
^"Etynodiol". Drugs.com. Archived from the original on 5 February 2018. Retrieved 4 February 2018.
^Cite error: The named reference Blum2013 was invoked but never defined (see the help page).
^ abCite error: The named reference pmid2256526 was invoked but never defined (see the help page).
^ abCite error: The named reference HumansOrganization2007 was invoked but never defined (see the help page).
^Cite error: The named reference TashjianArmstrong2011 was invoked but never defined (see the help page).
^Cite error: The named reference Becker2001 was invoked but never defined (see the help page).
^Cite error: The named reference GorollMulley2009 was invoked but never defined (see the help page).
^Cite error: The named reference pmid12215716 was invoked but never defined (see the help page).
^Cite error: The named reference Petrow_1971 was invoked but never defined (see the help page).
^Cite error: The named reference Publishing2013 was invoked but never defined (see the help page).
^"Ovulen: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 8 December 2022. Retrieved 20 January 2024.
^"Demulen: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 10 May 2021. Retrieved 20 January 2024.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Ethinyl Estradiol; Ethynodiol - Drug Usage Statistics". ClinCalc. Archived from the original on 18 January 2024. Retrieved 14 January 2024.
and 24 Related for: Etynodiol diacetate information
Etynodioldiacetate, or ethynodiol diacetate, sold under the brand name Ovulen among others, is a progestin medication which is used in birth control pills...
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Androstenediol diacetate, or 5-androstenediol 3β,17β-diacetate, also known as androst-5-ene-3β,17β-diol 3β,17β-diacetate, is a synthetic anabolic-androgenic...
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