Estradiol acetate (EA), sold under the brand names Femtrace, Femring, and Menoring, is an estrogen medication which is used in hormone therapy for the treatment of menopausal symptoms in women.[3][4][5][6] It is taken by mouth once daily or given as a vaginal ring once every three months.[2]
Side effects of estradiol acetate include breast tenderness, breast enlargement, nausea, headache, and fluid retention.[7][5][6] Estradiol acetate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol.[8][9] It is an estrogen ester and a prodrug of estradiol in the body.[9][8] Because of this, it is considered to be a natural and bioidentical form of estrogen.[9][10]
Estradiol acetate was introduced for medical use in 2001.[11] It is available in the United States and the United Kingdom.[11][3] The formulation for use by mouth has been discontinued in the United States.[12]
^"Estradiol: Uses, Dosage & Side Effects". Drugs.com. Retrieved 21 April 2023.
^ abCite error: The named reference pmid17506242 was invoked but never defined (see the help page).
^ ab"Estradiol Monograph for Professionals".
^Buckler H, Al-Azzawi F (August 2003). "The effect of a novel vaginal ring delivering oestradiol acetate on climacteric symptoms in postmenopausal women". BJOG. 110 (8): 753–759. doi:10.1016/s1470-0328(03)02908-2. PMID 12892687.
^ ab"Highlights of prescribing information" (PDF). accessdata.fda.gov. 2014. Retrieved 21 April 2023.
^ ab"FEMRING". DailyMed. U.S. National Library of Medicine.
^Cite error: The named reference Ghosh2010 was invoked but never defined (see the help page).
^ abKuhl H (August 2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric. 8 (Suppl 1): 3–63. doi:10.1080/13697130500148875. PMID 16112947. S2CID 24616324.
^ abcKuhnz W, Blode H, Zimmermann H (6 December 2012). "Pharmacokinetics of Exogenous Natural and Synthetic Estrogens and Antiestrogens". In Oettel M, Schillinger E (eds.). Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Handbook of Experimental Pharmacology. Vol. 135 / 2. Springer Science & Business Media. p. 261. doi:10.1007/978-3-642-60107-1_15. ISBN 978-3-642-60107-1. Natural estrogens considered here include: [...] Esters of 17β-estradiol, such as estradiol valerate, estradiol benzoate and estradiol cypionate. Esterification aims at either better absorption after oral administration or a sustained release from the depot after intramuscular administration. During absorption, the esters are cleaved by endogenous esterases and the pharmacologically active 17β-estradiol is released; therefore, the esters are considered as natural estrogens.
^Cirigliano M (June 2007). "Bioidentical hormone therapy: a review of the evidence". Journal of Women's Health. 16 (5): 600–631. doi:10.1089/jwh.2006.0311. PMID 17627398.
^ abCite error: The named reference pmid15382956 was invoked but never defined (see the help page).
^Cite error: The named reference Femtrace-FDA was invoked but never defined (see the help page).
Estradiolacetate (EA), sold under the brand names Femtrace, Femring, and Menoring, is an estrogen medication which is used in hormone therapy for the...
(4/95) in the estradiol undecylate group and 5.3% (5/96) in the cyproterone acetate group. There were five deaths in total, three in the estradiol undecylate...
latter, estradiol cypionate has been used in combination with medroxyprogesterone acetate as a combined injectable contraceptive. Along with estradiol valerate...
include estradiol cypionate, estradiol enantate, and estradiolacetate, the former two of which are C17β esters of estradiol similarly to estradiol valerate...
Norethisterone acetate (NETA), also known as norethindrone acetate and sold under the brand name Primolut-Nor among others, is a progestin medication...
by about 75%. The combination of 25 mg/day cyproterone acetate and a moderate dosage of estradiol has been found to suppress testosterone levels in transgender...
Estradiol enantate (EEn or E2-EN), also spelled estradiol enanthate and sold under the brand names Perlutal and Topasel among others, is an estrogen medication...
the intestines and liver. Estradiol is micronized and/or conjugated with an ester, as in estradiol valerate or estradiolacetate, to improve its oral bioavailability...
through scientific testing. Specific hormones used in BHT include estrone, estradiol, progesterone, testosterone, dehydroepiandrosterone (DHEA), and estriol...
major estradiol esters that are or have been used in medicine include estradiolacetate, estradiol cypionate, estradiol dipropionate, estradiol enantate...
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of female reproductive...
thromboembolism risk with oral CEEs plus medroxyprogesterone acetate and oral estradiol plus norethisterone acetate was found to be equivalent (RRTooltip Relative risk...
one-year contraceptive vaginal ring containing segesterone acetate in combination with ethinyl estradiol was approved in the United States. It is marketed under...
Estradiol pivalate, also known as estradiol trimethyl acetate (E2-TMA) and sold under the brand name Estrotate, is an estrogen medication and an estrogen...
with estradiol under the brand name Zoely. As Zoely, NOMAC has been studied in over 4,000 women as a method of birth control. Nomegestrol acetate is the...
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