Micrograph of confluent epidermal necrosis. H&E stain.
Specialty
Dermatology
In dermatology, erythema multiforme major is a form of rash with skin loss or epidermal detachment.
The term "erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation.[2]
According to some sources, there are two conditions included on a spectrum of this same disease process:
Stevens–Johnson syndrome (SJS)
Toxic epidermal necrolysis (TEN) which described by Alan Lyell and previously called Lyell syndrome[5].
In this view, EM major, SJS and TEN are considered a single condition, distinguished by degree of epidermal detachment.[3][4]
However, a consensus classification separates erythema multiforme minor, erythema multiforme major, and SJS/TEN as three separate entities.[3]
^Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
^Daniel J. Trozak; Dan J. Tennenhouse (1 October 2005). Dermatology skills for primary care: an illustrated guide. Humana Press. pp. 161–. ISBN 978-1-58829-489-0. Archived from the original on 21 June 2013. Retrieved 5 June 2010.
^ ab"Erythema Multiforme: eMedicine Emergency Medicine". 2019-02-02. Archived from the original on 2010-08-06. {{cite journal}}: Cite journal requires |journal= (help)
^Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC (January 1993). "Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme". Arch Dermatol. 129 (1): 92–6. doi:10.1001/archderm.129.1.92. PMID 8420497.[permanent dead link]
and 27 Related for: Erythema multiforme major information
moderate and one severe, are recognized (erythemamultiforme minor and erythemamultiformemajor). Erythemamultiforme was first described by von Hebra in...
with eosinophilia and systemic symptoms Erythemamultiformemajor (erythemamultiforme minor–erythemamultiforme von Hebra) Exudative hyponychial dermatitis...
Annular erythema of infancy (AEI) consists of self-limited eruptions of erythematous, annular to polycyclic patches and plaques. It is an idiopathic figurate...
aphthous-like ulceration include reactive arthritis, and recurrent erythemamultiforme. Diagnosis is mostly based on the clinical appearance and the medical...
including toxic or allergic reaction at the site of the vaccination (erythemamultiforme), spread of the vaccinia virus to other parts of the body, and spread...
with acute illnesses and injuries that require immediate attention Erythemamultiforme, a skin condition that usually follows an antecedent infection or...
sometimes termed (oral) erythema migrans, but this has no relation to the more common use of the term erythema migrans (erythema chronicum migrans), to...
"desert rheumatism" includes the combination of fever, joint pains, and erythema nodosum. A minority (3–5%) of infected individuals do not recover from...
infestation mirror other skin diseases, including dermatitis, syphilis, erythemamultiforme, various urticaria-related syndromes, allergic reactions, ringworm-related...
an enzyme of the melanocyte that catalyzes melanin biosynthesis, and a major autoantigen in generalized vitiligo. Vitiligo is sometimes associated with...
capillary-sized vessels.[predatory publisher] H&E stain. Histopathology of the major differential diagnosis of a well-differentiated liposarcoma, lipoma-like...
eating disorders, crash diets, pregnancy and childbirth, chronic illness, major surgery, anemia, severe emotional disorders, hypothyroidism, and drugs....
(papulovesicles) and less commonly target-shaped lesions which look like erythemamultiforme may be visible. In addition, it may occur in other parts of the body...
Bastiaens, M.; et al. (2001). "The melanocortin-1-receptor gene is the major freckle gene". Human Molecular Genetics. 10 (16): 1701–1708. doi:10.1093/hmg/10...
diffuse systemic form carries a worse prognosis than the limited form. The major scleroderma-related causes of death are: pulmonary hypertension, pulmonary...
is involved and an intermediate form with 10 to 30% involvement. Erythemamultiforme (EM) is generally considered a separate condition. Treatment typically...
Most of the identified genes relate to the immune system, particularly the major histocompatibility complex (MHC) and T cells. Genetic studies are valuable...
include behavioral changes (including suicidal thoughts), angioedema, erythemamultiforme, and liver problems. In 2019 and 2020, concerns for neuropsychiatric...
macules, papules or plaques of various thickness, often with surrounding erythema. They are usually 2–6mm in diameter but can sometimes reach several centimeters...