Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Ergothioneine is a naturally occurring amino acid and is a thiourea derivative of histidine, containing a sulfur atom on the imidazole ring.[1] This compound occurs in relatively few organisms, notably actinomycetota, cyanobacteria, and certain fungi.[2][3] Ergothioneine was discovered by Charles Tanret in 1909 and named after the ergot fungus from which it was first purified,[4] with its structure being determined in 1911.[5][6]
In humans, ergothioneine is acquired exclusively through the diet and accumulates in erythrocytes, bone marrow, liver, kidney, seminal fluid, and eyes.[7] Although the effect of ergothioneine in vivo is under preliminary research, its physiological role in humans is unknown.[7] Ergothioneine is sold as a dietary supplement.[8]
^"Ergothioneine". PubChem, National Center for Biotechnology Information, US National Library of Medicine. 2 November 2019. Retrieved 7 November 2019.
^Fahey RC (2001). "Novel thiols of prokaryotes". Annual Review of Microbiology. 55: 333–56. doi:10.1146/annurev.micro.55.1.333. PMID 11544359.
^Pfeiffer C, Bauer T, Surek B, Schömig E, Gründemann D (2011). "Cyanobacteria produce high levels of ergothioneine". Food Chemistry. 129 (4): 1766–1769. doi:10.1016/j.foodchem.2011.06.047.
^Tanret, C. (1909). "Sur une base nouvelle retirée du seigle ergoté : l'ergothioneine". Comptes rendus hebdomadaires des séances de l'Académie des sciences (in French). 149: 222-224.
^Barger, G.; Erwins, A.J. (1911). "The constitution of ergothioneine : a betaine related to histidine". Journal of the Chemical Society. Transactions. 99: 2336–2341.
^Cite error: The named reference Mann was invoked but never defined (see the help page).
Ergothioneine is a naturally occurring amino acid and is a thiourea derivative of histidine, containing a sulfur atom on the imidazole ring. This compound...
amino acid and the amino-octose bound to ergothioneine is then the substrate of LmbV, which substitute ergothioneine by mycothiol. The mycothiol moiety is...
had the highest amount of ergothioneine among the other saprotrophs within the group. List of Pleurotus species Ergothioneine Singer, R. (1943). "Das System...
known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter. The encoded protein is an integral protein of the plasma...
Selenoneine is a selenium containing ergothioneine derivative where the selenium (Se) atom replaces a sulfur atom. It can be systematically named as (2-selenyl-Nα...
Neurospora crassa, histidine can be converted into the antioxidant ergothioneine. The Food and Nutrition Board (FNB) of the U.S. Institute of Medicine...
phytochemicals, including 500 mg of ergosterol per 100 g of dried mushroom, and ergothioneine. The fruit bodies contain numerous polyphenols, especially a high content...
norepinephrine, MPP+ SLC22A4 Solute carrier family 22 member 4 Sodium ion and ergothioneine SLC22A5 Solute carrier family 22 member 5 Primary carnitine deficiency...
mutation was selected for, a mutation which probably arose to deal with ergothioneine deficiency but increases the risk of ulcerative colitis, coeliac disease...
the crucial glutathione synthesis pathway supports the production of ergothioneine and ophthalmate". Molecular Microbiology. 100 (1): 15–24. doi:10.1111/mmi...
respiratory medicine Epithelioid trophoblastic tumour, a very rare cancer Ergothioneine transporter, a protein and human gene (SLC22A4) Exercise Tolerance Test...
compounds codinaeopsin, efrapeptins, and antiamoebin. The fungal isolate ergothioneine is actively absorbed and concentrated by the human body via SLC22A4...
22-dien-3β-ol, uridine, allitol, ergosterol, ergosterol 5α,8α-peroside, ergothioneine, adenosine, and uracil have been identified from the mushrooms. List...
carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). Rheumatoid arthritis SLC16A11 Q8NCK7 Proton-linked monocarboxylate...
Encarnacion, Ph.D. Bureau of Fisheries and Aquatic Resources Application of ergothioneine-rich extract from an edible mushroom (Flammulina velutipes) for melanosis...
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