EpiVacCorona information

EpiVacCorona
	Package of EpiVacCorona vaccine
Vaccine description
Target	SARS-CoV-2
Vaccine type	Peptide subunit
Clinical data
Trade names	EpiVacCorona
Other names	EpiVacCorona-N, Aurora-CoV
Routes of; administration	Intramuscular
ATC code	J07BN (WHO) ;
Legal status
Legal status	RU: Registered on 14 October 2020; Full list of EpiVacCorona authorizations
Identifiers
DrugBank	DB16439;

EpiVacCorona (Russian: ЭпиВакКорона, tr. EpiVacCorona) is a peptide-based vaccine against COVID-19 developed by the Russian VECTOR Center of Virology.^[2]^[3] The lack of protective effectiveness of EpiVacCorona, which is still in use in Russia, has been reported in scientific literature^[4] and in the media.^[5]^[6] The vaccine consists of three chemically synthesized peptides (short fragments of a viral spike protein) that are conjugated to a large carrier protein. This protein is a fusion product of a viral nucleocapsid protein and a bacterial MBP protein. A phase III clinical trial to show whether or not the vaccine can protect people against COVID-19 was launched in November 2020 with more than three thousand participants. The conclusions and results of the trial have not been made public.^[7]^[8]

Some experts in the field have expressed concerns about the selection of peptides for use as vaccine antigens.^[9]^[10] In addition, there are also serious concerns about the vaccine immunogenicity data, which have fueled independent civic research efforts^[11]^[12]^[13] and criticism by some experts.^[9] Current Time TV reported that "EpiVacCorona's reputation declined when vaccine trial participants sent an open letter to the Ministry of Health to flag 18 cases of COVID-19 infection among their group after vaccination with EpiVacCorona, and a lack of virus antibodies".^[14]

^ ^a ^b "EpiVacCorona-N COVID-19 vaccine to be registered under Aurora-CoV brand name". Russian News Agency. 5 July 2021. Retrieved 6 July 2021.
^ Cite error: The named reference :3 was invoked but never defined (see the help page).
^ Ryzhikov AB, Ryzhikov EA, Bogryantseva MP, Danilenko ED, Imatdinov IR, Nechaeva EA, et al. (2021). "Immunogenicity and protectivity of the peptide vaccine against SARS-CoV-2". Annals of the Russian Academy of Medical Sciences. 76: 5–19. doi:10.15690/vramn1528. S2CID 234892966.
^ Matveeva O, Ershov A (June 2022). "Retrospective Cohort Study of the Effectiveness of the Sputnik V and EpiVacCorona Vaccines against the SARS-CoV-2 Delta Variant in Moscow (June-July 2021)". Vaccines. 10 (7): 984. doi:10.3390/vaccines10070984. PMC 9320764. PMID 35891148.
^ "Studies suggest 'negative efficacy' for vaccine EpiVacCorona". THE BELL. 1 February 2022. Retrieved 3 May 2022.
^ Ershov A (8 February 2022). "Worse than ineffective Two independent studies have confirmed that EpiVacCorona is a worthless vaccine — and it should be taken off the market". Meduza.
^ Clinical trial number NCT04780035 for "Multicenter Double-blind Placebo-controlled Comparative Randomized Study of the Tolerability, Safety, Immunogenicity and Prophylactic Efficacy of the EpiVacCorona Peptide Antigen-based Vaccine for the Prevention of COVID-19, With the Participation of 3000 Volunteers Aged 18 Years and Above (Phase III-IV)" at ClinicalTrials.gov
^ Tumakova I (21 August 2021). ""Мы хотим спасти людей от вакцины, если она неэффективна"". Novaya Gazeta. Retrieved 3 May 2022.
^ ^a ^b Dobrovidova O (6 April 2021). "Russia's COVID-19 defense may depend on mystery vaccine from former bioweapons lab—but does it work?". Science | AAAS. Retrieved 24 April 2021.
^ Dobrovidova O (April 2021). "Latest Russian vaccine comes with a big dose of mystery". Science. 372 (6538): 116–117. Bibcode:2021Sci...372..116D. doi:10.1126/science.372.6538.116. PMID 33833104. S2CID 233191522.
^ Reuters Staff (26 March 2021). "Volunteers break rank to raise doubts in trial of Russia's second COVID-19 vaccine". Reuters. Retrieved 23 April 2021.
^ ""ЭпиВакКорона" глазами участников клинических испытаний и ученых-биологов". Троицкий вариант — Наука (in Russian). 23 March 2021. Retrieved 23 April 2021.
^ Ershov A (27 March 2021). "Sputnik V's ugly cousin Clinical results for Russia's EpiVacCorona vaccine are finally here, but developers published in an obscure local journal, raising questions and concerns". Meduza.
^ "Russia's Domestic Manufacturers Struggle To Meet Spike In Demand For COVID-19 Vaccines". Current Time. 26 June 2021. Retrieved 3 May 2022.

[synonymsru-1] "EpiVacCorona-N COVID-19 vaccine to be registered under Aurora-CoV brand name". Russian News Agency. 5 July 2021. Retrieved 6 July 2021.

[:3-2] Cite error: The named reference :3 was invoked but never defined (see the help page).

[3] Ryzhikov AB, Ryzhikov EA, Bogryantseva MP, Danilenko ED, Imatdinov IR, Nechaeva EA, et al. (2021). "Immunogenicity and protectivity of the peptide vaccine against SARS-CoV-2". Annals of the Russian Academy of Medical Sciences. 76: 5–19. doi:10.15690/vramn1528. S2CID 234892966.

[:17-4] Matveeva O, Ershov A (June 2022). "Retrospective Cohort Study of the Effectiveness of the Sputnik V and EpiVacCorona Vaccines against the SARS-CoV-2 Delta Variant in Moscow (June-July 2021)". Vaccines. 10 (7): 984. doi:10.3390/vaccines10070984. PMC 9320764. PMID 35891148.

[:14-5] "Studies suggest 'negative efficacy' for vaccine EpiVacCorona". THE BELL. 1 February 2022. Retrieved 3 May 2022.

[:15-6] Ershov A (8 February 2022). "Worse than ineffective Two independent studies have confirmed that EpiVacCorona is a worthless vaccine — and it should be taken off the market". Meduza.

[:13-7] Clinical trial number NCT04780035 for "Multicenter Double-blind Placebo-controlled Comparative Randomized Study of the Tolerability, Safety, Immunogenicity and Prophylactic Efficacy of the EpiVacCorona Peptide Antigen-based Vaccine for the Prevention of COVID-19, With the Participation of 3000 Volunteers Aged 18 Years and Above (Phase III-IV)" at ClinicalTrials.gov

[:0-8] Tumakova I (21 August 2021). ""Мы хотим спасти людей от вакцины, если она неэффективна"". Novaya Gazeta. Retrieved 3 May 2022.

[:9-9] Dobrovidova O (6 April 2021). "Russia's COVID-19 defense may depend on mystery vaccine from former bioweapons lab—but does it work?". Science | AAAS. Retrieved 24 April 2021.

[:1-10] Dobrovidova O (April 2021). "Latest Russian vaccine comes with a big dose of mystery". Science. 372 (6538): 116–117. Bibcode:2021Sci...372..116D. doi:10.1126/science.372.6538.116. PMID 33833104. S2CID 233191522.

[:4-11] Reuters Staff (26 March 2021). "Volunteers break rank to raise doubts in trial of Russia's second COVID-19 vaccine". Reuters. Retrieved 23 April 2021.

[:5-12] ""ЭпиВакКорона" глазами участников клинических испытаний и ученых-биологов". Троицкий вариант — Наука (in Russian). 23 March 2021. Retrieved 23 April 2021.

[13] Ershov A (27 March 2021). "Sputnik V's ugly cousin Clinical results for Russia's EpiVacCorona vaccine are finally here, but developers published in an obscure local journal, raising questions and concerns". Meduza.

[14] "Russia's Domestic Manufacturers Struggle To Meet Spike In Demand For COVID-19 Vaccines". Current Time. 26 June 2021. Retrieved 3 May 2022.

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