An endotype is a subtype of a health condition, which is defined by a distinct functional or pathobiological mechanism.[1] This is distinct from a phenotype, which is any observable characteristic or trait of a disease, such as development, biochemical or physiological properties without any implication of a mechanism. It is envisaged that patients with a specific endotype present themselves within phenotypic clusters of diseases.
One example is asthma, which is considered to be a syndrome, consisting of a series of endotypes.[2] This is related to the concept of disease entity.
^Russell C, Baillie JK (April 2017). "Treatable traits and therapeutic targets: Goals for systems biology in infectious disease". Current Opinion in Systems Biology. 004 (3): 139–45. doi:10.1016/j.coisb.2017.04.003. PMC 7185428. PMID 32363252.
^Lötvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, Custovic A, Lemanske RF, Wardlaw AJ, Wenzel SE, Greenberger PA (February 2011). "Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome". The Journal of Allergy and Clinical Immunology. 127 (2): 355–60. doi:10.1016/j.jaci.2010.11.037. PMID 21281866.
An endotype is a subtype of a health condition, which is defined by a distinct functional or pathobiological mechanism. This is distinct from a phenotype...
into endotypes based on etiology. Where necessary to determine appropriate treatment differential diagnosis procedures are employed. An endotype is a...
Asthma phenotyping and endotyping is a novel approach to asthma classification inspired by precision medicine. It seeks to separate the clinical presentations...
dysfunction endotype (inability to dilate) tend to have a high vascular tone at rest and high vascular tone at stress. Patients with this endotype typically...
(Odds ratio 7.2, 95% confidence interval 5.2-10). Asthma phenotyping and endotyping has emerged as a novel approach to asthma classification inspired by precision...
understood as a nonspecific finding shared by a group of disease entities or endotypes. For example, concepts such as murrain and the grippe that were formerly...
providing a framework for endotype discovery using probabilistic modelling. She uses statistical models to identify the underlying endotypes of a condition from...
Carl; Keller, Christian; Bobbitt, Kevin R.; Ramesh, Mayur. "Inflammatory endotype of odontogenic sinusitis". International Forum of Allergy & Rhinology....
research. Projects are grouped broadly into the following six themes: Endotype Discovery. By combining clinical and genetic data researchers are able...
-D-galactopyranosyluronate endolyase. catalyses the following process: Endotype eliminative cleavage of L-α-rhamnopyranosyl-(1→4)-α-D-galactopyranosyluronic...
remodelling, or airway remodeling, is a potential complication of certain endotypes (subtypes) of asthma. It is the sum of changes that occur in the airways...
Rudzinski ER, et al. (2020). "Defining an embryonal rhabdomyosarcoma endotype". Cold Spring Harbor Molecular Case Studies. 6 (2): a005066. doi:10.1101/mcs...
Global Information