Connective tissue layer around myelinated nerve fibers in peripheral nervous system
Endoneurium
Transverse section of human tibial nerve.
Nerve structure
Details
Part of
myelin sheath of nerves
System
Nervous system
Identifiers
TA98
A14.2.00.014
TA2
6158
FMA
52586
Anatomical terminology
[edit on Wikidata]
The endoneurium (also called endoneurial channel, endoneurial sheath, endoneurial tube, or Henle's sheath) is a layer of delicate connective tissue around the myelin sheath of each myelinated nerve fiber in the peripheral nervous system.[1] Its component cells are called endoneurial cells.[2] The endoneuria with their enclosed nerve fibers are bundled into groups called nerve fascicles,[3] each fascicle within its own protective sheath called a perineurium.[3][4] In sufficiently large nerves multiple fascicles, each with its blood supply and fatty tissue, may be bundled within yet another sheath, the epineurium.
The endoneurium contains a liquid known as endoneurial fluid, which contains little protein. In the peripheral nervous system the endoneurial fluid is notionally equivalent to cerebrospinal fluid in the central nervous system. Peripheral nerve injuries commonly release increased amounts of endoneurial fluid into surrounding tissues; these can be detected by magnetic resonance neurography, thereby assisting in locating injuries to peripheral nerves.
The endoneurium runs longitudinally along the nerve fiber, but with discontinuities where septa pass inward from the innermost layer of the perineurium. It contains fine bundles of fibrous connective tissue, primarily collagen, embedded in a matrix of ground substance.[5] This structure serves to support capillary blood vessels, arranged so as to form a network of elongated meshes. Similar structures occur around some nervous components elsewhere in the body, for example around the Schwann cells on the peripheral side of the transitional zone on the auditory nerve.[6]
^"Neurohistology lecture" (PDF). Retrieved 27 April 2019.
^Elaine N. Marieb and Katja Hoehn (2007). Human Anatomy & Physhyphysiology (7th Ed.). Pearson. pp. 498–9. ISBN 978-0-8053-5909-1.
^ abBarral, Jean-Pierre; Croibier, Alain (2009-01-01), Barral, Jean-Pierre; Croibier, Alain (eds.), "Chapter 1 - Some preliminary thoughts", Manual Therapy for the Cranial Nerves, Edinburgh: Churchill Livingstone, pp. 1–5, doi:10.1016/b978-0-7020-3100-7.50004-5, ISBN 978-0-7020-3100-7, retrieved 2020-11-18
^Sheikh, Kazim A. (2005-01-01), Waxman, Stephen G. (ed.), "25 - AMAN: What It Teaches Us about Mechanisms Underlying Axonal Injury", Multiple Sclerosis As A Neuronal Disease, Burlington: Academic Press, pp. 355–371, doi:10.1016/b978-012738761-1/50026-2, ISBN 978-0-12-738761-1, retrieved 2020-11-18
^Reina, Miguel A.; Sala-Blanch, Xavier; Arriazu, Riánsares; Machés, Fabiola (2015-01-01), Tubbs, R. Shane; Rizk, Elias; Shoja, Mohammadali M.; Loukas, Marios (eds.), "Chapter 7 - Microscopic Morphology and Ultrastructure of Human Peripheral Nerves", Nerves and Nerve Injuries, San Diego: Academic Press, pp. 91–106, doi:10.1016/b978-0-12-410390-0.00007-x, ISBN 978-0-12-410390-0, retrieved 2020-11-18
^Fraher JP (2000). "The transitional zone and CNS regeneration". J. Anat. 196 (1): 137–58. PMID 10697296.
The endoneurium (also called endoneurial channel, endoneurial sheath, endoneurial tube, or Henle's sheath) is a layer of delicate connective tissue around...
each axon is surrounded by a layer of connective tissue called the endoneurium. The axons are bundled together into groups called fascicles, and each...
injury sensory-motor problems present distal to the site of injury intact endoneurium, perineurium, and the epineurium wallerian degeneration not present intact...
potentials (EPPs). Within motor nerves, each axon is wrapped by the endoneurium, which is a layer of connective tissue that surrounds the myelin sheath...
Inside the fascicles is the endoneurium, a tissue matrix analogous to the internal epineurium, and the nerve cells. The endoneurium has many small blood capillaries...
connective tissue surrounding each nerve are: Endoneurium. Each nerve axon, or fiber is surrounded by the endoneurium, which is also called the endoneurial tube...
axon in a nerve is wrapped in a delicate protective sheath known as the endoneurium. Fascicles, bundles of neurons, are surrounded by the perineurium. Several...
nerve fiber in the fascicle is enclosed by a connective tissue layer of endoneurium. Bundles of nerve fascicles are called fasciculi and are constituents...
arachnoid, and pia mater) rather than the epineurium, perineurium, and endoneurium found in peripheral nerves. Fiber tracts of the mammalian central nervous...
perimysium, and endomysium) and nerves (epineurium, perineurium, and endoneurium). The high density of collagen fibers gives the deep fascia its strength...
and their myelin sheath are damaged in this kind of injury, but the endoneurium, perineurium and epineurium remain intact. Motor and sensory functions...
This tortuous pattern of nerves is seen within a background of loose endoneurium-like fibrous stroma.[citation needed] Variations in the RET proto-oncogene...
is intact, and they have made contact with the Schwann cells in the endoneurium (also known as the endoneurial tube or channel). Human axon growth rates...
nerve is composed of a bundle of axons. Each axon is surrounded by the endoneurium connective tissue layer. These axons are bundled into fascicles surrounded...
the axons are surrounded by most often a myelinated sheath and then an endoneurium. A perineurium surrounds that and the outermost layer is considered the...
disruption of the nerve architecture sufficient to involve perineurium and endoneurium as well as axons and their covering. It requires surgery, with unpredictable...
growth. Connective tissue in the peripheral nervous system Perineurium Endoneurium Epimysium, a similar type of connective tissue which surrounds muscles...
injury demonstrated thickening of the walls of the microvessels in the endoneurium and perineurium along with epineurial and perineurial edema, thickening...
cells improve the electrical conduction. The myelin is surrounded by endoneurium, which is a protective sheath of connective tissue. This is surrounded...
disruption of nerve structures sufficient to involve perineurium and endoneurium as well as axons and their covering. Denervation changes recorded by...
dorsal root ganglion and posterior nerve roots and arise between the endoneurium and perineurium. Occasionally, these cysts are observed in the lumbar...
Recovery is not complete. Neurotmesis: this type of injury involves the endoneurium with wallerian degeneration. Recovery is difficult. There are several...
peripheral nervous system. It is present in the connective tissue of the endoneurium, perineurium, and epineurium. ColVI has been shown to be expressed by...
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