ESKAPE is an acronym comprising the scientific names of six highly virulent and antibiotic resistant bacterial pathogens including: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.[1] The acronym is sometimes extended to ESKAPEE to include Escherichia coli.[2] This group of Gram-positive and Gram-negative bacteria can evade or 'escape' commonly used antibiotics due to their increasing multi-drug resistance (MDR).[1] As a result, throughout the world, they are the major cause of life-threatening nosocomial or hospital-acquired infections in immunocompromised and critically ill patients who are most at risk.[3] P. aeruginosa and S. aureus are some of the most ubiquitous pathogens in biofilms found in healthcare.[4] P. aeruginosa is a Gram-negative, rod-shaped bacterium, commonly found in the gut flora, soil, and water that can be spread directly or indirectly to patients in healthcare settings.[5][6] The pathogen can also be spread in other locations through contamination, including surfaces, equipment, and hands. The opportunistic pathogen can cause hospitalized patients to have infections in the lungs (as pneumonia), blood, urinary tract, and in other body regions after surgery.[6] S. aureus is a Gram-positive, cocci-shaped bacterium, residing in the environment and on the skin and nose of many healthy individuals.[7] The bacterium can cause skin and bone infections, pneumonia, and other types of potentially serious infections if it enters the body. S. aureus has also gained resistance to many antibiotic treatments, making healing difficult.[7] Because of natural and unnatural selective pressures and factors, antibiotic resistance in bacteria usually emerges through genetic mutation or acquires antibiotic-resistant genes (ARGs) through horizontal gene transfer - a genetic exchange process by which antibiotic resistance can spread.[8]
One of the main reasons for the rise in the selection for antibiotic resistance (ABR) and MDR which led to the emergence of the ESKAPE bacteria is from the rash overuse of antibiotics not only in healthcare, but also in the animal, and agricultural sector.[9] Other key factors include misuse and inadequate adherence to treatment guidelines.[10] Due to these factors, fewer and fewer antibiotic treatments are effective in eradicating ABR and MDR bacterial infections, while at the same time there are now no new antibiotics being created due to lack of funding.[10] These ESKAPE pathogens, along with other antibiotic-resistant bacteria, are an interweaved global health threat and are being addressed from a more holistic and One Health perspective.[6][9]
^ abMulani MS, Kamble EE, Kumkar SN, Tawre MS, Pardesi KR (2019). "Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review". Frontiers in Microbiology. 10: 539. doi:10.3389/fmicb.2019.00539. PMC 6452778. PMID 30988669.
^Mahmood HY, Jamshidi S, Sutton JM, Rahman KM (2016). "Current Advances in Developing Inhibitors of Bacterial Multidrug Efflux Pumps". Current Medicinal Chemistry. 23 (10): 1062–1081. doi:10.2174/0929867323666160304150522. PMC 5425656. PMID 26947776.
^Rice LB (April 2008). "Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE". The Journal of Infectious Diseases. 197 (8): 1079–81. doi:10.1086/533452. PMID 18419525.
^Høiby N, Bjarnsholt T, Givskov M, Molin S, Ciofu O (April 2010). "Antibiotic resistance of bacterial biofilms". International Journal of Antimicrobial Agents. 35 (4): 322–32. doi:10.1016/j.ijantimicag.2009.12.011. PMID 20149602.
^Santajit S, Indrawattana N (2016-05-05). "Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens". BioMed Research International. 2016: 2475067. doi:10.1155/2016/2475067. PMC 4871955. PMID 27274985.
^ abcCDC (2019). "Antibiotic Resistance Threats in the United States" (PDF). Atlanta, GA: Centers for Disease Control and Prevention, U.S. Department of Health and Human Services.
^ abTaylor TA, Unakal CG (2020). "Staphylococcus Aureus". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 28722898. Retrieved 2020-11-13.
^ abCollignon PJ, McEwen SA (January 2019). "One Health-Its Importance in Helping to Better Control Antimicrobial Resistance". Tropical Medicine and Infectious Disease. 4 (1): 22. doi:10.3390/tropicalmed4010022. PMC 6473376. PMID 30700019.
^ abMa YX, Wang CY, Li YY, Li J, Wan QQ, Chen JH, et al. (January 2020). "Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections". Advanced Science. 7 (1): 1901872. doi:10.1002/advs.201901872. PMC 6947519. PMID 31921562.
ESKAPE is an acronym comprising the scientific names of six highly virulent and antibiotic resistant bacterial pathogens including: Enterococcus faecium...
Gram-negative bacteria of particular recent importance have been dubbed as the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae...
relevant members of the genus. A. baumannii has also been identified as an ESKAPE pathogen (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae...
; Scheld, M; Spellberg, B; Bartlett, J (2009). "Bad bugs, no drugs: No ESKAPE! An update from the Infectious Diseases Society of America". Clinical Infectious...
to execute Muhammad bin Qasim, avenging her parents, and then managed to eskape the captivity of the harem by having the Calph execute her and her sister...
residue of clindamycin. Iboxamycin has been found to be effective against ESKAPE bacteria, methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus...
Cliffs, a historic settlement site in the Northern Territory, Australia ESKAPE This disambiguation page lists articles associated with the title Escape...
S, Petrosillo N (February 2014). "Could chloramphenicol be used against ESKAPE pathogens? A review of in vitro data in the literature from the 21st century"...
Note: This Tape is made in Australia. 2 Insektors: The Eskape Featuring Episodes: The Eskape, Planet Karbon, Kolecopter and Katerpillar. Note: This Tape...
S2CID 46125592. Pandey R, Mishra SK, Shrestha A (2021). "Characterisation of ESKAPE Pathogens with Special Reference to Multidrug Resistance and Biofilm Production...
location was converted into a bowling and entertainment center known as "esKape" - and following a sale to the Brunswick Corporation, it was renovated into...
out to rescue him and blow up the Krud/Yuk boiler. 5 EsKapade The Eskape The EsKape Prince Max/Acylius is trying to escape the dark world again and crashes...
analyzed against 24 and 72 hour old biofilms of 11 clinically isolated ESKAPE pathogens (defined as Enterococcus faecium, Staphylococcus aureus, Klebsiella...
properties of medicinal plants from Pakistan against multidrug-resistant ESKAPE pathogens. Frontiers in pharmacology, 9. [1] Muhs, A., Lyles, J. T., Parlet...
in screening chemical compounds for antimicrobial activity against key ESKAPE pathogens, E. coli, K. pneumoniae, A. baumannii, P. aeruginosa, S. aureus...
department consists of various vocal and instrumental groups, including Chorus, eSKape, Jazz Band, Concert Band, and the Symphony Orchestra. The orchestra at South...
Madhumita S.; Pardesi, Karishma R. (2019-04-01). "Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review". Frontiers in...
related infections with special emphasis on Acinetobacter, Klebsiella, ESKAPE, Human microbiome and Thrombolysis. His studies have been documented by...
new singles were due to be released in Feb 2008, a rocked up version of "Eskape to the Muzic" which was very popular in USA, and a song entitled "Bajan...
sudnli komed to dey. Koz krans beed slim e lite, dey kaned flai skoro e eskaped tori-kachor’s nets. But guss non kaned eskap izli e al es kaptur koz dey...