ERRFI1 information

ERRFI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RF9, 2RFD, 2RFE, 4I21, 4R3P, 4R3R, 4ZJV
Identifiers
Aliases	ERRFI1, GENE-33, MIG-6, MIG6, RALT, ERBB receptor feedback inhibitor 1
External IDs	OMIM: 608069; MGI: 1921405; HomoloGene: 10344; GeneCards: ERRFI1; OMA:ERRFI1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	8,026,309 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	150,953,349 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; vena cava; ; right lobe of liver; ; tibialis anterior muscle; ; gastric mucosa; ; synovial joint; ; ascending aorta; ; synovial membrane; ; pancreatic epithelial cell; ; left uterine tube;
	Top expressed in
	left lobe of liver; ; gallbladder; ; kidney; ; right lung lobe; ; left lung; ; left lung lobe; ; carotid body; ; secondary oocyte; ; utricle; ; medullary collecting duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity; SH3 domain binding; kinase binding; protein binding; protein kinase binding; small GTPase binding;
Cellular component	membrane; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; nucleus; cytoplasm; cytosol;
Biological process	negative regulation of interleukin-1 beta production; negative regulation of epidermal growth factor receptor signaling pathway; skin morphogenesis; negative regulation of protein autophosphorylation; cellular response to platelet-derived growth factor stimulus; cellular response to dexamethasone stimulus; cellular response to epidermal growth factor stimulus; cellular hyperosmotic response; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of peptidyl-tyrosine phosphorylation; cellular response to insulin stimulus; negative regulation of ERK1 and ERK2 cascade; regulation of keratinocyte differentiation; lung alveolus development; lung vasculature development; lung epithelium development; regulation of type B pancreatic cell proliferation; negative regulation of collagen biosynthetic process; negative regulation of cardiac muscle hypertrophy in response to stress; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	54206
	74155
	ENSG00000116285
	ENSMUSG00000028967
	Q9UJM3
	Q99JZ7
	NM_018948
	NM_133753; NM_001356323
	NP_061821
	NP_598514; NP_001343252
	Wikidata
View/Edit Human	View/Edit Mouse

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.^[5]^[6]^[7]^[8]^[9]

MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116285 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028967 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM (June 2000). "Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress". The Journal of Biological Chemistry. 275 (23): 17838–47. doi:10.1074/jbc.M909735199. PMC 3668664. PMID 10749885.
^ Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK (August 1989). "Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity". Nucleic Acids Research. 17 (16): 6651–67. doi:10.1093/nar/17.16.6651. PMC 318357. PMID 2780291.
^ Fiorini M, Ballarò C, Sala G, Falcone G, Alemà S, Segatto O (September 2002). "Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene. 21 (42): 6530–9. doi:10.1038/sj.onc.1205823. PMID 12226756. S2CID 23762528.
^ Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alemà S, Benedetti P, Segatto O (October 2000). "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain". Molecular and Cellular Biology. 20 (20): 7735–50. doi:10.1128/MCB.20.20.7735-7750.2000. PMC 86354. PMID 11003669.
^ ^a ^b "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116285 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028967 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10749885-5] Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM (June 2000). "Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress". The Journal of Biological Chemistry. 275 (23): 17838–47. doi:10.1074/jbc.M909735199. PMC 3668664. PMID 10749885.

[pmid2780291-6] Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK (August 1989). "Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity". Nucleic Acids Research. 17 (16): 6651–67. doi:10.1093/nar/17.16.6651. PMC 318357. PMID 2780291.

[pmid12226756-7] Fiorini M, Ballarò C, Sala G, Falcone G, Alemà S, Segatto O (September 2002). "Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene. 21 (42): 6530–9. doi:10.1038/sj.onc.1205823. PMID 12226756. S2CID 23762528.

[pmid11003669-8] Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alemà S, Benedetti P, Segatto O (October 2000). "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain". Molecular and Cellular Biology. 20 (20): 7735–50. doi:10.1128/MCB.20.20.7735-7750.2000. PMC 86354. PMID 11003669.

[entrez-9] "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1".

ERRFI1 information

and 3 Related for: ERRFI1 information

ERRFI1

CDC42

Stratifin