dentate gyrus of hippocampal formation granule cell
lactiferous gland
choroid plexus of fourth ventricle
ankle joint
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
protein binding
lipid binding
Cellular component
cytoplasm
plasma membrane
clathrin-coated pit
membrane
nucleus
cytosol
Biological process
Notch signaling pathway
female pregnancy
negative regulation of epidermal growth factor receptor signaling pathway
in utero embryonic development
endocytosis
embryonic organ development
membrane organization
negative regulation of sprouting angiogenesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
29924
13854
Ensembl
ENSG00000063245
ENSMUSG00000035203
UniProt
Q9Y6I3
Q80VP1
RefSeq (mRNA)
NM_001130071 NM_001130072 NM_013333 NM_001321263
NM_001252454 NM_010147
RefSeq (protein)
NP_001123543 NP_001123544 NP_001308192 NP_037465
NP_001239383 NP_034277 NP_001359429
Location (UCSC)
Chr 19: 55.68 – 55.71 Mb
Chr 7: 5.08 – 5.1 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Epsin-1 is a protein that in humans is encoded by the EPN1 gene.[5][6][7]
EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles.[supplied by OMIM][7]
^ abcGRCh38: Ensembl release 89: ENSG00000063245 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000035203 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Sep 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. Bibcode:1998Natur.394..793C. doi:10.1038/29555. PMID 9723620. S2CID 4430975.
^Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (Dec 1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene. 18 (43): 5915–22. doi:10.1038/sj.onc.1202974. PMID 10557078.
Epsin-1 is a protein that in humans is encoded by the EPN1 gene. EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha...
been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms...
notch signaling. There are four human genes encoding epsin family members: EPN1, EPN2, EPN3, and EPN4. The epsin homologue of C. elegans is EPN-1. EPN-1...
been thoroughly characterized. EPS15 has been shown to interact with: CRK EPN1, HGS, HRB, and REPS2. GRCh38: Ensembl release 89: ENSG00000085832 – Ensembl...
humans is encoded by the AP2A2 gene. AP2A2 has been shown to interact with EPN1 and SHC1. ENSG00000280759, ENSG00000183020 GRCh38: Ensembl release 89: ENSG00000281385...
isoforms have been found for this gene. REPS2 has been shown to interact with EPN1, EPS15 and RALBP1. GRCh38: Ensembl release 89: ENSG00000169891 – Ensembl...
Global Information
