ELP4 information

ELP4
Identifiers
Aliases	ELP4, AN, C11orf19, PAX6NEB, PAXNEB, dJ68P15A.1, helongator acetyltransferase complex subunit 4, AN2
External IDs	OMIM: 606985 MGI: 1925016 HomoloGene: 32433 GeneCards: ELP4
Gene location (Human)
Chr.	Chromosome 11 (human)
End	31,790,324 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	105,734,909 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; secondary oocyte; ; islet of Langerhans; ; ganglionic eminence; ; cerebellar hemisphere; ; frontal pole; ; palpebral conjunctiva; ; rectum; ; body of pancreas; ; popliteal artery;
	Top expressed in
	primitive streak; ; ciliary body; ; neural tube; ; iris; ; ganglionic eminence; ; maxillary prominence; ; ureter; ; spermatocyte; ; facial motor nucleus; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone acetyltransferase activity; RNA polymerase II complex binding; phosphorylase kinase regulator activity; protein binding;
Cellular component	cytoplasm; elongator holoenzyme complex; histone acetyltransferase complex; transcription elongation factor complex; nucleus; nucleoplasm;
Biological process	regulation of transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; regulation of transcription, DNA-templated; histone H3 acetylation; transcription, DNA-templated; histone H4 acetylation; regulation of protein kinase activity; tRNA wobble uridine modification;
	Sources:Amigo / QuickGO
Orthologs
	26610
	77766
	ENSG00000109911
	ENSMUSG00000027167
	Q96EB1
	Q9ER73
	NM_001288725; NM_001288726; NM_019040
	NM_023876
	NP_001275654; NP_001275655; NP_061913
	NP_076365
	Wikidata
View/Edit Human	View/Edit Mouse

Elongation protein 4 homolog (S. cerevisiae), also known as ELP4, is a protein which in humans is encoded by the ELP4 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109911 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027167 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ELP4 elongation protein 4 homolog (S. cerevisiae)".
^ Winkler GS, Petrakis TG, Ethelberg S, Tokunaga M, Erdjument-Bromage H, Tempst P, Svejstrup JQ (August 2001). "RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes". J. Biol. Chem. 276 (35): 32743–9. doi:10.1074/jbc.M105303200. PMID 11435442.
^ Kleinjan DA, Seawright A, Elgar G, van Heyningen V (February 2002). "Characterization of a novel gene adjacent to PAX6, revealing synteny conservation with functional significance". Mamm. Genome. 13 (2): 102–7. doi:10.1007/s00335-001-3058-y. PMID 11889558. S2CID 23006323.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109911 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027167 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ELP4 elongation protein 4 homolog (S. cerevisiae)".

[pmid11435442-6] Winkler GS, Petrakis TG, Ethelberg S, Tokunaga M, Erdjument-Bromage H, Tempst P, Svejstrup JQ (August 2001). "RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes". J. Biol. Chem. 276 (35): 32743–9. doi:10.1074/jbc.M105303200. PMID 11435442.

[pmid11889558-7] Kleinjan DA, Seawright A, Elgar G, van Heyningen V (February 2002). "Characterization of a novel gene adjacent to PAX6, revealing synteny conservation with functional significance". Mamm. Genome. 13 (2): 102–7. doi:10.1007/s00335-001-3058-y. PMID 11889558. S2CID 23006323.

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