EIF2B5 information

EIF2B5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JUI
Identifiers
Aliases	EIF2B5, CACH, CLE, EIF-2B, EIF2Bepsilon, LVWM, eukaryotic translation initiation factor 2B subunit epsilon
External IDs	OMIM: 603945; MGI: 2446176; HomoloGene: 2903; GeneCards: EIF2B5; OMA:EIF2B5 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	184,146,127 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	20,328,073 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; tendon of biceps brachii; ; gastrocnemius muscle; ; anterior pituitary; ; right hemisphere of cerebellum; ; middle temporal gyrus; ; minor salivary glands; ; mucosa of transverse colon; ; granulocyte; ; right lobe of thyroid gland;
	Top expressed in
	spermatocyte; ; epiblast; ; morula; ; morula; ; lacrimal gland; ; muscle of thigh; ; spermatid; ; ventricular zone; ; tail of embryo; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	translation initiation factor activity; guanyl-nucleotide exchange factor activity; protein binding; translation initiation factor binding;
Cellular component	cytoplasm; eukaryotic translation initiation factor 2B complex; nucleus; cytosol;
Biological process	astrocyte development; human ageing; response to peptide hormone; response to heat; response to glucose; response to endoplasmic reticulum stress; astrocyte differentiation; ovarian follicle development; myelination; oligodendrocyte development; positive regulation of translational initiation; hippocampus development; translational initiation; response to lithium ion; protein biosynthesis; positive regulation of apoptotic process; positive regulation of translation; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8893
	224045
	ENSG00000145191
	ENSMUSG00000003235
	Q13144
	Q8CHW4
	NM_003907
	NM_172265
	NP_003898
	NP_758469
	Wikidata
View/Edit Human	View/Edit Mouse

Translation initiation factor eIF-2B subunit epsilon is a protein that in humans is encoded by the EIF2B5 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145191 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003235 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Asuru AI, Mellor H, Thomas NS, Yu L, Chen JJ, Crosby JS, Hartson SD, Kimball SR, Jefferson LS, Matts RL (Jul 1996). "Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human". Biochimica et Biophysica Acta. 1307 (3): 309–17. doi:10.1016/0167-4781(96)00054-1. PMID 8688466.
^ "Entrez Gene: EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145191 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003235 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8688466-5] Asuru AI, Mellor H, Thomas NS, Yu L, Chen JJ, Crosby JS, Hartson SD, Kimball SR, Jefferson LS, Matts RL (Jul 1996). "Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human". Biochimica et Biophysica Acta. 1307 (3): 309–17. doi:10.1016/0167-4781(96)00054-1. PMID 8688466.

[entrez-6] "Entrez Gene: EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa".

EIF2B5 information

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