EIF2B2 information

EIF2B2
Identifiers
Aliases	EIF2B2, EIF-2Bbeta, EIF2B, eukaryotic translation initiation factor 2B subunit beta, EIF2Bbeta
External IDs	OMIM: 606454; MGI: 2145118; HomoloGene: 6507; GeneCards: EIF2B2; OMA:EIF2B2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	75,012,366 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	85,273,402 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; right adrenal cortex; ; gastrocnemius muscle; ; left adrenal gland; ; muscle of thigh; ; left adrenal cortex; ; popliteal artery; ; tibial arteries; ; mucosa of transverse colon;
	Top expressed in
	condyle; ; fossa; ; renal corpuscle; ; internal carotid artery; ; external carotid artery; ; endocardial cushion; ; saccule; ; yolk sac; ; substantia nigra; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	translation initiation factor activity; guanyl-nucleotide exchange factor activity; GTP binding; protein binding; ATP binding;
Cellular component	cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex;
Biological process	response to peptide hormone; response to heat; response to glucose; central nervous system development; cell metabolism; ovarian follicle development; myelination; oligodendrocyte development; regulation of translational initiation; protein biosynthesis; translational initiation; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8892
	217715
	ENSG00000119718
	ENSMUSG00000004788
	P49770
	Q99LD9
	NM_014239
	NM_145445
	NP_055054
	NP_663420
	Wikidata
View/Edit Human	View/Edit Mouse

Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119718 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004788 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yang W, Hinnebusch AG (December 1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2". Mol Cell Biol. 16 (11): 6603–16. doi:10.1128/MCB.16.11.6603. PMC 231662. PMID 8887689.
^ "Entrez Gene: EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119718 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004788 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8887689-5] Yang W, Hinnebusch AG (December 1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2". Mol Cell Biol. 16 (11): 6603–16. doi:10.1128/MCB.16.11.6603. PMC 231662. PMID 8887689.

[entrez-6] "Entrez Gene: EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa".

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