Dobutamine is a medication used in the treatment of cardiogenic shock (as a result of inadequate tissue perfusion) and severe heart failure.[2][3] It may also be used in certain types of cardiac stress tests.[2] It is given by IV only, as an injection into a vein or intraosseous as a continuous infusion.[2] The amount of medication needs to be adjusted to the desired effect.[2] Onset of effects is generally seen within 2 minutes.[2] It has a half-life of two minutes. This drug is generally only administered short term, although it may be used for longer periods to relieve symptoms of heart failure in patients awaiting heart transplantation.[4]
Common side effects include a fast heart rate, an irregular heart beat, and inflammation at the site of injection.[2][5] Use is not recommended in those with idiopathic hypertrophic subaortic stenosis.[2] It primarily works by direct stimulation of β1 receptors, which increases the strength of the heart's contractions, leading to a positive inotropic effect. Generally it has little effect on a person's heart rate.[2]
Dobutamine was approved for medical use in the United States in 1978.[2] It is available as a generic medication.[5] It was initially made from isoproterenol.[3]
^ ab"Dobutamine (Dobutrex) Use During Pregnancy". Drugs.com. 18 March 2020. Retrieved 17 May 2020.
^ abcdefghijk"Dobutamine Hydrochloride Monograph for Professionals". Drugs.com. AHFS. Retrieved 11 January 2019.
^ abWilson WC, Grande CM, Hoyt DB (2007). Trauma: Critical Care. CRC Press. p. 302. ISBN 978-1-4200-1684-0.
^Gentile P, Marini C, Ammirati E, Perna E, Saponara G, Garascia A, et al. (October 2021). "Long-term administration of intravenous inotropes in advanced heart failure". ESC Heart Failure. 8 (5): 4322–4327. doi:10.1002/ehf2.13394. PMC 8497373. PMID 34191408.
^ abBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 220–221. ISBN 978-0-85711-338-2.
Dobutamine is a medication used in the treatment of cardiogenic shock (as a result of inadequate tissue perfusion) and severe heart failure. It may also...
patient is subjected to stress in the form of exercise or chemically (often dobutamine). After the target heart rate is achieved, 'stress' echocardiogram images...
sensitize adrenoreceptors to catecholamines; and others (e.g. dopamine, dobutamine) increase cardiac output. If low blood pressure is due to blood loss,...
level in patients in the levosimendan group compared with patients in the dobutamine group, levosimendan did not significantly reduce all-cause mortality at...
which improves during a low-dose dobutamine stress test is classified as "hibernating myocardium." Low dose dobutamine stimulates contractile function...
increases the consumption of oxygen and energy to the same degree as dobutamine but in diseased hearts it may not. Pimobendan also causes peripheral vasodilation...
attempts to open the heart's arteries may help. Certain medications, such as dobutamine and milrinone, improve the heart's ability to contract and can also be...
β2-agonist. Other examples include phenylephrine, isoproterenol, and dobutamine. Stimulation of the D1 receptor by dopaminergic agonists such as fenoldopam...
rule out infection or cancer. Other treatments may include the use of dobutamine or in those with low blood volume, intravenous fluids. Those with few...
not used often, as more established drugs like epinephrine, dopamine, dobutamine, norepinephrine, and levosimendan work as well. It works by stimulating...
treatment of cardiac decompensation can be achieved through administration of dobutamine, resulting in an increase in heart contractility via an inotropic effect...
kidneys. Dobutamine can also be used in hypotensive septic shock to increase cardiac output and correct blood flow to the tissues. Dobutamine is not used...
CT scan. IVUS cardiac catheterization including dFFR measured during dobutamine challenge – from which readings of dFFR and percentage compression as...
craniotomy), severe pulmonary congestion, or pulmonary edema. Dextrose and dobutamine are both used to increase blood flow to the kidney and act within 30 to...
Nordin, A. J.; Mäkisalo, H.; Höckerstedt, K. A. (1996-08-31). "Failure of dobutamine to improve liver oxygenation during resuscitation with a crystalloid solution...
diuretic.[medical citation needed] Metoclopramide[medical citation needed] Dobutamine, a direct-acting beta agonist used in congestive heart failure, also demonstrates...
Atropine will counteract bradycardia, glucagon helps with hypoglycemia, dobutamine can be given against hypotension and the inhalation of a β2-mimetic such...
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