Hyberbolic relationship between insulin sensitivity and beta cell function showing dynamical compensation in "healthy" insulin resistance (transition from A to B) and the evolution of type 2 diabetes mellitus (transition from A to C). Disposition metrics integrate beta cell function and insulin sensitivity in a way so that the results remain constant across dynamical compensation. Changed from Cobelli et al. 2007 and Hannon et al. 2018[1][2]
The Disposition index (DI) is a measure for the loop gain of the insulin-glucose feedback control system. It is defined as the product of insulin sensitivity times the amount of insulin secreted in response to blood glucose levels.[3][4] "Metabolically healthy" Insulin resistant individuals can maintain normal responses to blood glucose due to the fact that higher levels of insulin are secreted as long as the beta cells of the pancreas are able to increase their output of insulin to compensate for the insulin resistance. But the ratio of the incremental increase in plasma insulin associated with an incremental increase in plasma glucose (disposition index) provides a better measure of beta cell function than the plasma insulin response to a glucose challenge.[5] Loss of function of the beta cells, reducing their capacity to compensate for insulin resistance, results in a lower disposition index.[3]
^Cobelli C, Toffolo GM, Dalla Man C, Campioni M, Denti P, Caumo A, Butler P, Rizza R (July 2007). "Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests". American Journal of Physiology. Endocrinology and Metabolism. 293 (1): E1–E15. doi:10.1152/ajpendo.00421.2006. PMID 17341552.
^Hannon TS, Kahn SE, Utzschneider KM, Buchanan TA, Nadeau KJ, Zeitler PS, Ehrmann DA, Arslanian SA, Caprio S, Edelstein SL, Savage PJ, Mather KJ, RISE C (January 2018). "Review of methods for measuring β-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium". Diabetes, Obesity & Metabolism. 20 (1): 14–24. doi:10.1111/dom.13005. PMC 6095472. PMID 28493515.
^ abBergman RN, Ader M, Huecking K, Van Citters G (2002). "Accurate assessment of beta-cell function: the hyperbolic correction". Diabetes. 51 (Supp 1): S212–S220. doi:10.2337/diabetes.51.2007.s212. PMID 11815482.
^Ferrannini E, Mari A (May 2004). "Beta cell function and its relation to insulin action in humans: a critical appraisal". Diabetologia. 47 (5): 943–56. doi:10.1007/s00125-004-1381-z. PMID 15105990.
^Defronzo RA (2009). "Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus". Diabetes. 58 (4): 773–795. doi:10.2337/db09-9028. PMC 2661582. PMID 19336687.
The Dispositionindex (DI) is a measure for the loop gain of the insulin-glucose feedback control system. It is defined as the product of insulin sensitivity...
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resort to a normalization of beta cell function based on a disposition metric. The dispositionindex, calculated as product of insulin sensitivity and beta...
META Science Citation Index Drug Metabolism and Disposition, High Wire, retrieved 17 August 2010 Drug Metabolism and Disposition, National Library of Medicine...
Rewers MJ, Karter AJ, Bergman RN, Hanley AJ, et al. (September 2010). "Dispositionindex, glucose effectiveness, and conversion to type 2 diabetes: the Insulin...
History The Military Aircraft Storage and Disposition Center, April 1946 – May 1974". Air Force History Index. Retrieved 14 December 2013. Suciu, Peter...
exclusively on the performance of institutions, but also on the citizens' own dispositions and commitment. Data on democracy, and particularly global indices of...
(indexical of increasing affect) by one person who "looks like a woman" and another who looks "like a man" may index different affective dispositions which...
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Quimby, p. 358 Cruikshank, p. 93 for units, strengths, commanders and dispositions; Index, pp. iii, iv, x, xi, xv and xvii for the respective Christian names...
the index is zero-based, the steps are as follows: Index k = 2, because 3 is placed at an index that satisfies condition of being the largest index that...
that you can claim against taxable capital gains you realized from the disposition of certain capital properties”. Only residents from Canada throughout...
the United States contain records of arrests, criminal charges and the disposition of those charges. Criminal records are compiled and updated on local...
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g. a person actively thinking "snow is white"), but can instead be dispositional (e.g. a person who if asked about the color of snow would assert "snow...
gets along with his former bandmates and speculates that, given his disposition and skill-set, he might have been better able to contribute to the band...
along with the Sinai Peninsula are on the African Plate. This tectonic disposition leads to a relatively high seismic activity. The entire Jordan Valley...
information from the Form 4473 into a "bound-book", called an "Acquisition and Disposition Log”. The dealer must keep the Form 4473 on file for the lifetime of...
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