The disposable soma theory of aging states that organisms age due to an evolutionary trade-off between growth, reproduction, and DNA repair maintenance.[1] Formulated by Thomas Kirkwood, the disposable soma theory explains that an organism only has a limited amount of resources that it can allocate to its various cellular processes.[2] Therefore, a greater investment in growth and reproduction would result in reduced investment in DNA repair maintenance, leading to increased cellular damage, shortened telomeres, accumulation of mutations, compromised stem cells, and ultimately, senescence. Although many models, both animal and human, have appeared to support this theory, parts of it are still controversial.
Specifically, while the evolutionary trade-off between growth and aging has been well established,
the relationship between reproduction and aging is still without scientific consensus, and the cellular mechanisms largely undiscovered.[3]
^Kirkwood, T. (1977). "Evolution of ageing". Nature. 270 (5635): 301–304. Bibcode:1977Natur.270..301K. doi:10.1038/270301a0. PMID 593350. S2CID 492012.
^Gavrilov LA, Gavrilova NS (2002). "Evolutionary theories of aging and longevity". ScientificWorldJournal. 7 (2): 339–356. doi:10.1100/tsw.2002.96. PMC 6009642. PMID 12806021.
^Blagosklonny, MV (2010). "Why the disposable soma theory cannot explain why women live longer and why we age". Aging. 2 (12): 884–887. doi:10.18632/aging.100253. PMC 3034172. PMID 21191147.
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