Digitoxin is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia. It is a phytosteroid and is similar in structure and effects to digoxin, though the effects are longer-lasting. Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in patients with poor or erratic kidney function. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective.[1]
^Belz GG, Breithaupt-Grögler K, Osowski U (2001). "Treatment of congestive heart failure--current status of use of digitoxin". European Journal of Clinical Investigation. 31 (Suppl 2): 10–7. doi:10.1046/j.1365-2362.2001.0310s2010.x. PMID 11525233. Archived from the original on 2013-01-05.
Digitoxin is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia. It is a phytosteroid and is similar in...
(the strawberry foxglove) Due to the presence of the cardiac glycoside digitoxin, the leaves, flowers and seeds of this plant are all poisonous to humans...
the biosynthesis of calotropin is similar to that of digitoxin, another cardenolide. Digitoxin is more established as a medicine for cardiac insufficiency...
occurring steroids that are found in plants. Examples include digoxin, digitoxin, diosgenin, and guggulsterone, as well as phytosterols like β-sitosterol...
membranes. Digitonin is sometimes confused with the cardiac drugs digoxin and digitoxin; all three can be extracted from the same source. Critical micelle concentration...
Digitoxigenin, a cardenolide, is the aglycone of digitoxin. Digitoxigenin can be used to prepare actodigin. In Lednicer's book on steroids, it is made...
cardenolides, all parts are toxic. Its leaves contain 0.2% glycosides of the digitoxin-type and about 0,1% of the digoxin-type. Even so, the plant is not used...
Acetyldigitoxin is a cardiac glycoside. It is an acetyl derivative of digitoxin, found in the leaves of Digitalis species. It is used to treat cardiac...
include oral administration of activated charcoal. Ovine polyclonal anti-digitoxin Fab fragment antibody (DigiTAb; Therapeutic Antibodies Inc.) can be used...
for a reduction in dose or a switch to a different glycoside, such as digitoxin (not available in the United States), which has a much longer elimination...
growth, and in pure form are referred to by common chemical names, such as digitoxin or digoxin, or by brand names such as Crystodigin and Lanoxin, respectively...
(PDF) on October 9, 2012. Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41...
plants including foxglove and lily of the valley. They include digoxin and digitoxin which act as diuretics. Senna alexandrina, containing anthraquinone glycosides...
mortality (7.6%) was noted in a case series of acute and chronic digoxin and digitoxin poisoning despite Fab being used first line. Further, a retrospective...
plants including foxglove and lily of the valley. They include digoxin and digitoxin which support the beating of the heart, and act as diuretics. Senna alexandrina...
paricalcitol's metabolism in the liver. Digitoxin, hypercalcaemia due to any cause can exacerbate the toxicity of digitoxin. Thiazide diuretics or calcium supplements...
PMID 15641774. Karowe, DN; Golston, V (2006). "Effect of the cardenolide digitoxin on performance of gypsy moth (Lymantria dispar) (Lepidoptera: Lymantriidae)...
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