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Dermcidin information


DCD
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesDCD, AIDD, DCD-1, DSEP, HCAP, PIF, dermcidin
External IDsOMIM: 606634; HomoloGene: 89039; GeneCards: DCD; OMA:DCD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_053283
NM_001300854

n/a

RefSeq (protein)

NP_001287783
NP_444513

n/a

Location (UCSC)Chr 12: 54.64 – 54.65 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Dermcidin is a protein with 110 amino acids that in humans is encoded by the DCD gene.[3][4] The full-length protein produces derived peptides as proteolysis-inducing factor (PIF) and other anti-microbial peptides,[4] secreted by human eccrine sweat glands onto the skin as a part of the innate host defense of the immune system. PIF is involved in muscular proteolysis.[4]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161634 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Schittek B, Hipfel R, Sauer B, Bauer J, Kalbacher H, Stevanovic S, Schirle M, Schroeder K, Blin N, Meier F, Rassner G, Garbe C (Nov 2001). "Dermicidin: a novel human antibiotic peptide secreted by sweat glands". Nat Immunol. 2 (12): 1133–7. doi:10.1038/ni732. PMID 11694882. S2CID 26126901.
  4. ^ a b c "Entrez Gene: DCD dermicidin".

and 7 Related for: Dermcidin information

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Dermcidin

Last Update:

Dermcidin is a protein with 110 amino acids that in humans is encoded by the DCD gene. The full-length protein produces derived peptides as proteolysis-inducing...

Word Count : 1224

Eccrine sweat gland

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lactate, cytokines, immunoglobulins, antimicrobial peptides such as dermcidin, and many others. Relative to the plasma and extracellular fluid, the...

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DCD

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known as developmental dyspraxia, a type of motor learning difficulty Dermcidin, an anti-microbial peptide released by human sweat glands Donation after...

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Perspiration

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Eberhard-Karls University in Tübingen, Germany, isolated a large protein called dermcidin from skin. This protein, which could be cleaved into other antimicrobial...

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Innate immune system

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Anatomical barrier Additional defense mechanisms Skin Sweat (including dermcidin), cathelicidin, desquamation, flushing, organic acids, skin flora Gastrointestinal...

Word Count : 4797

Antimicrobial peptides

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peptides rich in glutamic and aspartic acids Maximin H5 from amphibians, dermcidin from humans Linear cationic α-helical peptides lack in cysteine Cecropins...

Word Count : 6545

Stress granule

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DAZ Associated Protein 2 DAZL DAZL1 Deleted In Azoospermia Like DCD DCD Dermcidin DCP1A DCP1a Decapping mRNA 1a yes DCP1B DCP1b Decapping mRNA 1b yes DCP2...

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