Dermcidin information

DCD
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2YMK, 2KSG
Identifiers
Aliases	DCD, AIDD, DCD-1, DSEP, HCAP, PIF, dermcidin
External IDs	OMIM: 606634; HomoloGene: 89039; GeneCards: DCD; OMA:DCD - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	54,648,493 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of hip; ; skin of abdomen; ; gonad; ; gastrocnemius muscle; ; right adrenal cortex; ; nipple; ; sural nerve; ; subcutaneous adipose tissue; ; popliteal artery;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; protein binding; hydrolase activity; RNA binding;
Cellular component	extracellular exosome; extracellular matrix; extracellular region; extracellular space;
Biological process	defense response to bacterium; proteolysis; antimicrobial humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism; defense response to fungus;
	Sources:Amigo / QuickGO
Orthologs
	117159
	n/a
	ENSG00000161634
	n/a
	P81605
	n/a
	NM_053283; NM_001300854
	n/a
	NP_001287783; NP_444513
	n/a
	Wikidata
View/Edit Human

Dermcidin is a protein with 110 amino acids that in humans is encoded by the DCD gene.^[3]^[4] The full-length protein produces derived peptides as proteolysis-inducing factor (PIF) and other anti-microbial peptides,^[4] secreted by human eccrine sweat glands onto the skin as a part of the innate host defense of the immune system. PIF is involved in muscular proteolysis.^[4]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161634 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schittek B, Hipfel R, Sauer B, Bauer J, Kalbacher H, Stevanovic S, Schirle M, Schroeder K, Blin N, Meier F, Rassner G, Garbe C (Nov 2001). "Dermicidin: a novel human antibiotic peptide secreted by sweat glands". Nat Immunol. 2 (12): 1133–7. doi:10.1038/ni732. PMID 11694882. S2CID 26126901.
^ ^a ^b ^c "Entrez Gene: DCD dermicidin".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000161634 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11694882-3] Schittek B, Hipfel R, Sauer B, Bauer J, Kalbacher H, Stevanovic S, Schirle M, Schroeder K, Blin N, Meier F, Rassner G, Garbe C (Nov 2001). "Dermicidin: a novel human antibiotic peptide secreted by sweat glands". Nat Immunol. 2 (12): 1133–7. doi:10.1038/ni732. PMID 11694882. S2CID 26126901.

[entrez-4] "Entrez Gene: DCD dermicidin".

Dermcidin information

and 7 Related for: Dermcidin information

Dermcidin

Eccrine sweat gland

Perspiration

DCD

Innate immune system

Antimicrobial peptides

Stress granule