Global InformationDecellularization of porcine heart valve information
Decellularization of porcine heart valves is the removal of cells along with antigenic cellular elements[1] by either physical or chemical decellularization of the tissue.[2] This decellularized valve tissue provides a scaffold with the remaining extracellular matrix (ECM) that can then be used for tissue engineering and valve replacement in humans inflicted with valvular disease.[3] Decellularized biological valves have potential benefit over conventional valves through decreased calcification which is thought to be an immuno-inflammatory response initiated by the recipient.[4]
- ^ Cebotari S, Tudorache I, Jaekel T, Hilfiker A, Dorfman S, Ternes W, et al. (March 2010). "Detergent decellularization of heart valves for tissue engineering: toxicological effects of residual detergents on human endothelial cells". Artificial Organs. 34 (3): 206–10. doi:10.1111/j.1525-1594.2009.00796.x. PMID 20447045.
- ^ Kasimir MT, Rieder E, Seebacher G, Silberhumer G, Wolner E, Weigel G, et al. (May 2003). "Comparison of different decellularization procedures of porcine heart valves". The International Journal of Artificial Organs. 26 (5): 421–7. doi:10.1177/039139880302600508. PMID 12828309. S2CID 28085063.
- ^ Schenke-Layland K, Vasilevski O, Opitz F, König K, Riemann I, Halbhuber KJ, et al. (September 2003). "Impact of decellularization of xenogeneic tissue on extracellular matrix integrity for tissue engineering of heart valves". Journal of Structural Biology. 143 (3): 201–8. doi:10.1016/j.jsb.2003.08.002. PMID 14572475.
- ^ Bloch O, Golde P, Dohmen PM, Posner S, Konertz W, Erdbrügger W (October 2011). "Immune response in patients receiving a bioprosthetic heart valve: lack of response with decellularized valves". Tissue Engineering. Part A. 17 (19–20): 2399–405. doi:10.1089/ten.TEA.2011.0046. PMID 21557643. S2CID 36527124.