DMP1 information

DMP1
Identifiers
Aliases	DMP1, ARHP, ARHR, DMP-1, dentin matrix acidic phosphoprotein 1
External IDs	OMIM: 600980; MGI: 94910; HomoloGene: 68396; GeneCards: DMP1; OMA:DMP1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	87,664,361 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	104,361,968 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; tibia; ; trabecular bone; ; sperm; ; upper respiratory tract; ; sensory nervous system; ; occipital lobe; ; testicle; ; thoracic aorta; ; ascending aorta;
	Top expressed in
	body of femur; ; fossa; ; molar; ; cochlea; ; calvaria; ; ankle; ; facial motor nucleus; ; condyle; ; otolith organ; ; utricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; integrin binding; extracellular matrix binding;
Cellular component	cytoplasm; extracellular region; nucleus; endoplasmic reticulum lumen; extracellular matrix;
Biological process	biomineral tissue development; extracellular matrix organization; ossification; positive regulation of cell-substrate adhesion; regulation of enamel mineralization; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	1758
	13406
	ENSG00000152592
	ENSMUSG00000029307
	Q13316
	O55188
	NM_001079911; NM_004407
	NM_016779; NM_001359013
	NP_001073380; NP_004398
	NP_058059; NP_001345942
	Wikidata
View/Edit Human	View/Edit Mouse

Dentin matrix acidic phosphoprotein 1 is a protein that in humans is encoded by the DMP1 gene.^[5]^[6]^[7]

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family (other members being DSPP, IBSP, MEPE, and SPP1). This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152592 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029307 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aplin HM, Hirst KL, Crosby AH, Dixon MJ (Mar 1996). "Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21". Genomics. 30 (2): 347–9. doi:10.1006/geno.1995.9867. PMID 8586437.
^ Hirst KL, Simmons D, Feng J, Aplin H, Dixon MJ, MacDougall M (Jul 1997). "Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II". Genomics. 42 (1): 38–45. doi:10.1006/geno.1997.4700. PMID 9177774.
^ ^a ^b "Entrez Gene: DMP1 dentin matrix acidic phosphoprotein".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152592 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029307 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8586437-5] Aplin HM, Hirst KL, Crosby AH, Dixon MJ (Mar 1996). "Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21". Genomics. 30 (2): 347–9. doi:10.1006/geno.1995.9867. PMID 8586437.

[pmid9177774-6] Hirst KL, Simmons D, Feng J, Aplin H, Dixon MJ, MacDougall M (Jul 1997). "Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II". Genomics. 42 (1): 38–45. doi:10.1006/geno.1997.4700. PMID 9177774.

[entrez-7] "Entrez Gene: DMP1 dentin matrix acidic phosphoprotein".

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