DHR2 (DOCK homology region 2), also known as CZH2 or Docker2, is a protein domain of approximately 450-550 amino acids that is present in the DOCK family of proteins.[1] This domain functions as a guanine nucleotide exchange factor (GEF) domain for small G proteins of the Rho family.[2] DHR2 domains bear no significant similarity to the well described DH domain (Dbl homologous domain) present in other RhoGEFs such as Vav, P-Rex and TRIO. Indeed, the most divergent mammalian DHR2 domains share only 16-17% sequence similarity.
^Meller N, Merlot S, Guda C (November 2005). "CZH proteins: a new family of Rho-GEFs". J. Cell Sci. 118 (Pt 21): 4937–46. doi:10.1242/jcs.02671. PMID 16254241.
^Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell Sci. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077.
DHR2 (DOCK homology region 2), also known as CZH2 or Docker2, is a protein domain of approximately 450-550 amino acids that is present in the DOCK family...
domain is also present in other proteins beyond RhoGEFs. The DHR2domain is the catalytic domain of the DOCK family of Rho GEFs. Like DH domain, DHR2...
core domains (known as DHR1 and DHR2), which are shared by all DOCK family members. The C-terminal DHR2domain functions as an atypical GEF domain for...
has a similar domain arrangement to other DOCK proteins, with a DHR1 domain known in other proteins to bind phospholipids, and a DHR2domain containing the...
domain arrangement as other members of the DOCK-D/Zizimin subfamily and shares the highest level of sequence identity with Dock9. It contains a DHR2 domain...
to the DHR2domain. Binding to ELMO requires the atypical PH domain of ELMO and also involves an interaction between the N-terminal SH3 domain of DOCK...
same domain arrangement as other members of the DOCK-D/Zizimin subfamily as well as a high level of sequence similarity. It contains a DHR2domain that...
canonical structure of tandem DH-PH domains known to elicit nucleotide exchange. Instead they possess a DHR2domain which mediates G protein activation...
canonical structure of tandem DH-PH domains known to elicit nucleotide exchange. Instead they possess a DHR2domain which mediates Rac activation by stabilising...
same core domain arrangement as all other DOCK proteins, with a DHR2domain which, in other proteins, contains GEF activity and a DHR1 domain known, in...
canonical structure of tandem DH-PH domains known to elicit nucleotide exchange. Instead they possess a DHR2domain which mediates Rac activation by stabilising...
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