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Cyclen information


Cyclen
Names
Preferred IUPAC name
1,4,7,10-Tetrazacyclododecane
Other names
Tetraaza-12-crown-4
Identifiers
CAS Number
  • 294-90-6 checkY
3D model (JSmol)
  • Interactive image
  • Interactive image
ChEBI
  • CHEBI:37391 checkY
ChEMBL
  • ChEMBL19880 checkY
ChemSpider
  • 58488 checkY
ECHA InfoCard 100.102.391 Edit this at Wikidata
PubChem CID
  • 64963
UNII
  • 964584YO2O checkY
CompTox Dashboard (EPA)
  • DTXSID60183621 Edit this at Wikidata
InChI
  • InChI=1S/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2 checkY
    Key: QBPPRVHXOZRESW-UHFFFAOYSA-N checkY
  • InChI=1/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2
    Key: QBPPRVHXOZRESW-UHFFFAOYAQ
SMILES
  • N1CCNCCNCCNCC1
  • C1CNCCNCCNCCN1
Properties
Chemical formula
C8H20N4
Molar mass 172.276 g·mol−1
Appearance White solid
Melting point 110–113 °C (230–235 °F; 383–386 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Cyclen (1,4,7,10-tetraazacyclododecane) is a aza-crown ether with the formula (CH2CH2NH)4. It is a white solid. Being structurally simple, symmetrical, and polyfunctional, cyclen has been widely investigated.[1]

  1. ^ Lejault, Pauline; Duskova, Katerina; Bernhard, Claire; Valverde, Ibai E.; Romieu, Anthony; Monchaud, David (2019). "The Scope of Application of Macrocyclic Polyamines Beyond Metal Chelation" (PDF). European Journal of Organic Chemistry. 2019 (36): 6146–6157. doi:10.1002/ejoc.201900870. S2CID 201220297.

and 22 Related for: Cyclen information

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Cyclen

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Cyclen (1,4,7,10-tetraazacyclododecane) is a aza-crown ether with the formula (CH2CH2NH)4. It is a white solid. Being structurally simple, symmetrical...

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Norgestimate

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Norgestimate, sold under the brand names Ortho Tri-Cyclen and Previfem among others, is a progestin medication which is used in birth control pills for...

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Ethinylestradiol

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Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins. In the past, EE was widely...

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Dithiooxamide

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of copper. It has also been used as a building block in the synthesis of cyclen. GHS: PubChem "Stainsfile - Howell's rubeanic acid for copper". stainsfile...

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Birth control pill formulations

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Kelnor, Barr) 250 μg norgestimate (UK: Cilest, Janssen-Cilag; US: Ortho Cyclen, Ortho-McNeil; MonoNessa, Watson; Sprintec, Barr; Sweden: Amorest) 2000 μg...

Word Count : 2003

Polyamine

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polyamines analogous to crown ethers: 1,4,7-triazacyclononane ((NHCH2CH2)3) and cyclen ((NHCH2CH2)4). A related tetraaza macrocycle is cyclam. Tris(2-aminoethyl)amine...

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DOTAM

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with a reactive linking group of para-isothiocyanatobenzyl attached to the cyclen ring is also of interest as a bifunctional chelator (BFC). Brennecke, Benjamin;...

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Ortho

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musculoskeletal system Ortho-DOT, a psychedelic drug Ortho-cept and Ortho Tri-cyclen, kinds of oral contraceptive drug Orthodoxy, right (correct) belief Orthopraxy...

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List of progestogens available in the United States

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Mili, Mono-Linyah, Ortho Cyclen-21, Ortho Cyclen-28, Ortho Tri-Cyclen, Ortho Tri-Cyclen 21, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Previfem, Sprintec...

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Amine alkylation

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1-benzylindole, and azetidine. Another example is found in the derivatization of cyclen. Industrially, ethylenediamine is produced by alkylation of ammonia with...

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Robert Wood Johnson I

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Nizoral Neomycin/polymyxin B/bacitracin o.b. OneTouch Ultra Ortho Tri-Cyclen Ortho-Cyclen Ortho-Novum Pancreatic Prucalopride Quisinostat Rabeprazole Reach...

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Cyclam

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alternating five- and six-membered chelate rings. The closely related ligand cyclen ((CH2CH2NH)4) forms only five-membered C2N2M chelate rings and tends not...

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Macrocyclic ligand

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complex of a thia-crown ether [Ag(18-ane-S6)]2+ Crystal structure of a Zn(II)-cyclen-ethanol dication. Fe-TAML complex. 1,4,7-Triazacyclononane is a tridentate...

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Ortho Pharmaceutical

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Cyclen containing the first new progestin (norgestimate) approved in over 20 years in the United States. In 1992, Ortho introduced Ortho Tri-Cyclen in...

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Combined oral contraceptive pill

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Retrieved 1 February 2013. "DailyMed - ORTHO TRI CYCLEN- norgestimate and ethinyl estradiol ORTHO CYCLEN- norgestimate and ethinyl estradiol". dailymed...

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List of progestogen esters

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(norethindrone enanthate; Noristerat, Norigest) Norgestimate (Ortho-Cyclen, Ortho Tri-Cyclen, Previfem, Sprintec, Prefest) Quingestanol acetate (Demovis, Pilomin...

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SN1CB mechanism

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ISBN 0-13-035471-6. Clark, C. R. and Buckingham, D. A., "Alkaline hydrolysis of [Co(cyclen)(O2CO)]+ and direct observation of deprotonated SN1CB intermediates", Inorganica...

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Tetradentate ligand

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(NHCH2CH2NHCH2CH2CH2)2 ring NNNN 200.33 transition metals 1,4,7,10-tetraazacyclododecane cyclen ring N4 172.271 Zn Dibenzotetramethyltetraaza[14]annulene tmtaa ring NNNN...

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Bushveld Igneous Complex

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cycles, Type II-UCZ base cycles, Type III-thin intermediate layer within cyclens, Type IV-stringers associated to OPX pegmatoids. Upper Critical Zone: Approximately...

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Herbert Ratner

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Quarterly 9:349–76, 1970. Physicians’ Package Insert, Ortho Tri-Cyclen Tablets and Ortho Cyclen Tablets, 2005. Carter, Richard. Breakthrough: The Saga of Jonas...

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Norelgestromin

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Pharmaceuticals. U.S. Food and Drug Administration. November 2017. "ORTHO-CYCLEN and ORTHO TRI-CYCLEN (norgestimate/ethinyl estradiol) tablets, for oral use" (PDF)...

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List of estrogen esters

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include: Diethylstilbestrol dipropionate (Agostilben, Biokeral, Clinestrol, Cyclen, Estilbin, Estril, Neobenzoestrol, Orestol, Oroestrol, Ostregenin, Prostilbene...

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