Crenezumab is a fully humanized monoclonal antibody against human 1-40 and 1-42 beta amyloid, which is being investigated as a treatment of Alzheimer's disease.[1] Crenezumab is highly homologous to solanezumab, another monoclonal antibody targeting amyloid-β peptides.[2] In June 2022, the US National Institutes of Health announced that the drug failed as a medication for early-onset Alzheimer's disease following the results of a decade-long clinical trial.[3]
^"Statement On A Nonproprietary Name Adopted By The USAN Council: Crenezumab" (PDF). American Medical Association.
^Crespi GA, Hermans SJ, Parker MW, Miles LA (April 2015). "Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies". Scientific Reports. 5: 9649. Bibcode:2015NatSR...5E9649C. doi:10.1038/srep09649. PMC 4549621. PMID 25880481.
^Hodes, Richard J. (16 June 2022). "NIA statement on crenezumab trial results: Anti-amyloid drug did not demonstrate a statistically significant clinical benefit in people with inherited form of Alzheimer's disease". National Institute on Aging. Retrieved 22 June 2022.
Crenezumab is a fully humanized monoclonal antibody against human 1-40 and 1-42 beta amyloid, which is being investigated as a treatment of Alzheimer's...
C6442H9966N1706O2018S40 (molar mass: 144.88 kg/mol) may refer to: Carlumab Crenezumab This set index page lists chemical structure articles associated with...
and were tested in clinical trials included aducanumab, bapineuzumab, crenezumab, gantenerumab, lecanemab, and solanezumab. Imaging compounds, notably...
for treatment of AD include Bapineuzumab, Solanezumab, Gautenerumab, Crenezumab, Aducanemab, Lecanemab and Donanemab. Bapineuzumab, a humanized anti-Aβ...
authors list (link) Banner Research Institute home page "NIA statement on crenezumab trial results: Anti-amyloid drug did not demonstrate a statistically significant...