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Coma cocktail
Specialty
emergency medicine
[edit on Wikidata]
A coma cocktail is a combination of substances administered in an emergency to comatose individuals when the cause of the coma has not yet been determined.[1] The intention is to work against various causes of a coma seen in an emergency setting including drug overdoses and hypoglycemia. The coma cocktail is sometimes colloquially referred to as a “party pack” by professionals in the pre-hospital emergency medical services field.[2]
Coma-cocktail
A standard combination included dextrose (1 Amp D50W IV), flumazenil (0.2 mg IV), naloxone (2 mg IV), and thiamine (100 mg IV).[3] It has been suggested that the use of naloxone and flumazenil be administered more selectively than glucose and thiamine.[4]
Some have proposed that the concept be abandoned completely because modern EMS providers should be able to determine the likely etiology of the change in mental status. At a minimum, the clinical presentation of the patient should rule in or out some portions of the coma cocktail.[5] For example, with the advent and widespread implementation of glucometers, the indications for administering glucose can be more narrowly defined and its use more regimented.[6]
^Bartlett D (December 2004). "The coma cocktail: indications, contraindications, adverse effects, proper dose, and proper route". J Emerg Nurs. 30 (6): 572–4. doi:10.1016/j.jen.2004.09.002. PMID 15565045.
^"Making Light: Sweetness and Light".
^Doyon S, Roberts JR (May 1994). "Reappraisal of the "coma cocktail". Dextrose, flumazenil, naloxone, and thiamine". Emerg. Med. Clin. North Am. 12 (2): 301–16. doi:10.1016/S0733-8627(20)30429-6. PMID 8187685.
^Buylaert WA (December 2000). "Coma induced by intoxication". Acta Neurol Belg. 100 (4): 221–4. PMID 11233676.
^Bledsoe BE (November 2002). "No more coma cocktails. Using science to dispel myths & improve patient care". Journal of Emergency Medical Services. 27 (11): 54–60. PMID 12483195.
^Sivilotti, Marco L.A. (7 August 2015). "Flumazenil, naloxone and the 'coma cocktail'". British Journal of Clinical Pharmacology. 81 (3): 428–436. doi:10.1111/bcp.12731. PMC 4767210. PMID 26469689.
A comacocktail is a combination of substances administered in an emergency to comatose individuals when the cause of the coma has not yet been determined...
PMID 16880774. Sivilotti, Marco L. A. (2016). "Flumazenil, naloxone and the 'comacocktail'". British Journal of Clinical Pharmacology. 81 (3): 428–436. doi:10...
CD004477. Sivilotti ML (March 2016). "Flumazenil, naloxone and the 'comacocktail'". British Journal of Clinical Pharmacology. 81 (3): 428–36. doi:10...
patient with altered consciousness. Controversies in the use of a 'comacocktail'". JAMA. 274 (7): 562–9. doi:10.1001/jama.274.7.562. PMID 7629986. Nelson...
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walking, and vomiting. Extreme doses may result in a respiratory depression, coma, or death. Complications may include seizures, aspiration pneumonia, low...
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Dean Berkowitz Herschel Sparber as E.J. Brad Braeden as Troy Lorissa McComas as Susan Kimber West as Bridget Jamie Anderson as Tiffany Claudia Pichardo...
survive the attack, but one is in a serious condition and the other in a coma. Sam soon discovers that Irons was a ruthless businessman who targeted his...
general shape to a grand piano and has been compared to a piano glued to a cocktail bar-sized satellite dish. As a point of departure, the team took inspiration...
and newspaper stories. It's also the kind of item that can come up in a cocktail party conversation when the subject turns to science or technology. [....
Rehab before he woke up from his coma. Anal Cunt's 1997 album I Like It When You Die contained the track "You're in a Coma". Putnam's reaction to the resulting...
Kovtun was hospitalized, with some sources initially reporting him to be in a coma. On 9 December, German police found traces of radiation at a Hamburg flat...
Review, Cameron Hilditch described the movement as: [a] toxic ideological cocktail of grievance, paranoia, and self-exculpatory rage ... Their aim was to...
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