Coagulative necrosis is a type of accidental cell death typically caused by ischemia or infarction. In coagulative necrosis, the architectures of dead tissue are preserved for at least a couple of days.[1] It is believed that the injury denatures structural proteins as well as lysosomal enzymes, thus blocking the proteolysis of the damaged cells. The lack of lysosomal enzymes allows it to maintain a "coagulated" morphology for some time. Like most types of necrosis, if enough viable cells are present around the affected area, regeneration will usually occur. Coagulative necrosis occurs in most bodily organs, excluding the brain.[2] Different diseases are associated with coagulative necrosis, including acute tubular necrosis and acute myocardial infarction.[2]
Coagulative necrosis can also be induced by high local temperature; it is a desired effect of treatments such as high intensity focused ultrasound applied to cancerous cells.[3]
^V, Abbas AK, Fausto B, Aster JC (2010). Robbins and Cotran: Pathologic Basis of Disease (8th ed.). Elsevier Health Sciences. p. 15. ISBN 978-1-4377-2015-0.
^Wu F, Wang ZB, Cao YD, Chen WZ, Bai J, Zou JZ, Zhu H (December 2003). "A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer". British Journal of Cancer. 89 (12): 2227–33. doi:10.1038/sj.bjc.6601411. PMC 2395272. PMID 14676799.
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maintains a cheese-like appearance. It is also a distinctive form of coagulativenecrosis. The dead tissue appears as a soft and white proteinaceous dead cell...
condition that results from acute gastric necrosis. The tarry black colour is produced by the coagulativenecrosis of mucosa resulting in intramucosal haemorrhage...
eosinophilic cytoplasm but without a nucleus. The ghost cells indicate coagulativenecrosis where there is cell death but retainment of cellular architecture...
myocardial infarction presents as a circumscribed area of ischemic, coagulativenecrosis (cell death). On gross examination, the infarct is not identifiable...
considered a type of cellular necrosis. Two types of myocytolysis have been defined: coagulative and colliquative. Coagulative myocytolysis appears in the...
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protein, causing death of the affected retinal cells and coagulativenecrosis. Laser coagulation has been used in people with sickle cell retinopathy. A...
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diabetes and long-term tobacco smoking. Dry gangrene is a form of coagulativenecrosis that develops in ischemic tissue, where the blood supply is inadequate...
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