A clostridial vaccine is a vaccine for sheep and cattle that protects against diseases caused by toxins produced by an infection with one or more Clostridium bacteria.[1] Clostridial vaccines are often administered to pregnant ewes a few weeks before they are due to give birth, in order to give passive immunity to their lambs.[1] Clostridial bacteria multiply rapidly in infected sheep, and produce large amounts of toxin which can cause the sheep to die within hours.[2]
Clostridial vaccines can contain anti-toxins to one or more endotoxins produced by the following bacteria:[1]
Clostridium chauvoei
Clostridium haemolyticum
Clostridium novyi
Clostridium perfringens
Clostridium septicum
Clostridium sordellii
Clostridium tetani
Clostridial vaccines which protect sheep against multiple clostridial diseases have been available since the 1950s.[3]
^ abcDuncanson, Graham R. (2012). "Vaccines for sheep. Clostridial diseases". Veterinary Treatment of Sheep and Goats. CABI. p. 97. ISBN 9781780640051.
^Scott, Phillip R. (2006). "Clostridial diseases". Sheep Medicine. CRC Press. p. 125. ISBN 9781840765366.
^Sargison, Neil (2009). Sheep flock health: a planned approach. John Wiley & Sons. p. 263. ISBN 9781444302608.
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ISBN 9781498700153. Winter, AC (2012). "Chapter 10: Sudden death: Main clostridial diseases". A handbook for the sheep clinician (7th ed.). Wallingford:...
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heating it to more than 85 °C (185 °F) for longer than five minutes. The clostridial spores can be destroyed in the autoclave with moist heat (120°C/ 250°F...
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link] Pellegrini LL, O'Connor V, Lottspeich F, Betz H (October 1995). "Clostridial neurotoxins compromise the stability of a low energy SNARE complex mediating...
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Kent. Here, he successfully elucidated the clostridial diseases of sheep, developing a polyvalent vaccine which transformed the economics of sheep farming...
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