The enzyme chorismate lyase (EC 4.1.3.40) catalyzes the first step in ubiquinone biosynthesis, the removal of pyruvate from chorismate, to yield 4-hydroxybenzoate in Escherichia coli and other Gram-negative bacteria.[1] It belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is chorismate pyruvate-lyase (4-hydroxybenzoate-forming). Other names in common use include CL, CPL, and UbiC.
This enzyme catalyses the chemical reaction:[2]
chorismate 4-hydroxybenzoate + pyruvate
The chorismate pyruvate lyase (CPL) catalyzed reaction.
Its activity does not require metal cofactors.[3]
^Nichols BP, Green JM (August 1992). "Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase". J. Bacteriol. 174 (16): 5309–16. doi:10.1128/jb.174.16.5309-5316.1992. PMC 206367. PMID 1644758.
^"EC 4.1.3.40".
^Siebert M, Severin K, Heide L (April 1994). "Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase". Microbiology. 140 (4): 897–904. doi:10.1099/00221287-140-4-897. PMID 8012607.
The enzyme chorismatelyase (EC 4.1.3.40) catalyzes the first step in ubiquinone biosynthesis, the removal of pyruvate from chorismate, to yield 4-hydroxybenzoate...
names in common use include anthranilate synthetase, chorismatelyase, and chorismate pyruvate-lyase (amino-accepting). This enzyme participates in phenylalanine...
synthase and 4-amino-4-deoxychorismate lyase. Chorismatelyase is an enzyme that transforms chorismate into 4-hydroxybenzoate and pyruvate. This enzyme...
\rightleftharpoons } chorismate + phosphate This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates...
synthase (EC 2.6.1.85) is an enzyme that catalyzes the chemical reaction chorismate + L-glutamine ⇌ {\displaystyle \rightleftharpoons } 4-amino-4-deoxychorismate...
Isochorismate lyase is a structural homolog of the chorismate mutase enzyme in E. coli, and actually exhibits non-physiological chorismate mutase activity...
also occur in several biological processes: Claisen rearrangement of chorismate to prephenate in almost all prototrophic organisms [1,5]-sigmatropic shift...
transformed into chorismate by a chorismate synthase. Prephenic acid is then synthesized by a Claisen rearrangement of chorismate by chorismate mutase. Prephenate...
family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is prephenate hydro-lyase (decarboxylating;...
family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is L-arogenate hydro-lyase (decarboxylating;...
moiety of PBP is first assembled from a chorismate precursor which is then converted by Bmp6, a chorismatelyase (CL), to yield 4-HBA. 4-HBA is then di-halogenated...
through various enzymes derived from the shikimic-chorismic acid pathway. Chorismate mutase then converts chorismic acid to prephenate via a Claisen rearrangement...
pathway. In the synthesis of L-phenylalanine, chorismate undergoes a Claisen rearrangement by a Chorismate mutase enzyme to form prephenate. Prephenate...
encodes the first subunit, which binds to chorismate and moves the amino group from the donor to chorismate. trpG encodes the second subunit, which facilitates...
flavin-C(4a)-(hydro)peroxide. Chorismate synthase (CS) catalyzes the last step in the shikimate pathway—the formation of chorismate. Two classes of CS are known...
stereochemistry at the third carbon. Chorismate mutase is an intramolecular transferase and it catalyzes the conversion of chorismate to prephenate, used as a precursor...
Mutant Bacillus subtilis Adenylosuccinate Lyase Equivalent to a Mutant Enzyme Found in Human Adenylosuccinate Lyase Deficiency: Asparagine 276 Plays an Important...
Global Information
