In computational biology, a Cellular Potts model (CPM, also known as the Glazier-Graner-Hogeweg model) is a computational model of cells and tissues. It is used to simulate individual and collective cell behavior, tissue morphogenesis and cancer development. CPM describes cells as deformable objects with a certain volume, that can adhere to each other and to the medium in which they live. The formalism can be extended to include cell behaviours such as cell migration, growth and division, and cell signalling. The first CPM was proposed for the simulation of cell sorting by François Graner and James A. Glazier as a modification of a large-Q Potts model.[1] CPM was then popularized by Paulien Hogeweg for studying morphogenesis.[2]
Although the model was developed to describe biological cells, it can also be used to model individual parts of a biological cell, or even regions of fluid.
^Graner, François; Glazier, James (1992). "Simulation of biological cell sorting using a two-dimensional extended Potts model". Phys. Rev. Lett.69 (13): 2013–7. Bibcode:1992PhRvL..69.2013G. doi:10.1103/PhysRevLett.69.2013. PMID 10046374.
^Savill, Nicholas J.; Hogeweg, Paulien (1997). "Modelling Morphogenesis: From Single Cells to Crawling Slugs". J. Theor. Biol.184 (3): 229–235. Bibcode:1997JThBi.184..229S. doi:10.1006/jtbi.1996.0237. hdl:1874/1405. PMID 31940735. S2CID 1611700.
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00320010060005. PMID 4332591. Holick MF, MacLaughlin JA, Clark MB, Holick SA, Potts JT, Anderson RR, et al. (October 1980). "Photosynthesis of previtamin D3...
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1007/s00381-007-0434-2. ISSN 0256-7040. PMID 17680251. S2CID 16163137. Potts, Richard (October 2012). "Evolution and Environmental Change in Early Human...
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