Cation diffusion facilitators (CDFs) are transmembrane proteins that provide tolerance of cells to divalent metal ions, such as cadmium, zinc, and cobalt. These proteins are considered to be efflux pumps that remove these divalent metal ions from cells.[1][2] However, some members of the CDF superfamily are implicated in ion uptake.[3] All members of the CDF family possess six putative transmembrane spanners with strongest conservation in the four N-terminal spanners.[4] The Cation Diffusion Facilitator (CDF) Superfamily includes the following families:[4][5]
1.A.52 - The Ca2+ Release-activated Ca2+ (CRAC) Channel (CRAC-C) Family
2.A.4 - The Cation Diffusion Facilitator (CDF) Family
2.A.19 - The Ca2+:Cation Antiporter (CaCA) Family
2.A.103 - The Bacterial Murein Precursor Exporter (MPE) Family
^Xiong A, Jayaswal RK (August 1998). "Molecular characterization of a chromosomal determinant conferring resistance to zinc and cobalt ions in Staphylococcus aureus". J. Bacteriol. 180 (16): 4024–9. doi:10.1128/JB.180.16.4024-4029.1998. PMC 107394. PMID 9696746.
^Kunito T, Kusano T, Oyaizu H, Senoo K, Kanazawa S, Matsumoto S (April 1996). "Cloning and sequence analysis of czc genes in Alcaligenes sp. strain CT14". Biosci. Biotechnol. Biochem. 60 (4): 699–704. doi:10.1271/bbb.60.699. PMID 8829543.
^Conklin DS, McMaster JA, Culbertson MR, Kung C (September 1992). "COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae". Mol. Cell. Biol. 12 (9): 3678–88. doi:10.1128/mcb.12.9.3678. PMC 360222. PMID 1508175.
^ abCite error: The named reference :3 was invoked but never defined (see the help page).
(CRAC) Channel (CRAC-C) Family 2.A.4 - The CationDiffusionFacilitator (CDF) Family 2.A.19 - The Ca2+:Cation Antiporter (CaCA) Family 2.A.103 - The Bacterial...
Facilitateddiffusion (also known as facilitated transport or passive-mediated transport) is the process of spontaneous passive transport (as opposed to...
(CRAC) Channel (CRAC-C) Family (TC# 1.A.52) is a member of the CationDiffusionFacilitator (CDF) Superfamily. These proteins typically have between 4 and...
Format"), the ANDI/netCDF scientific data interchange file format Cationdiffusionfacilitator, transport protein Channel Definition Format, an XML standard...
precursor exporter (MPE) family (TC# 2.A.103) is a member of the cationdiffusionfacilitator (CDF) superfamily of membrane transporters. Members of the MPE...
assist in the movement of substances by facilitateddiffusion, active transport, osmosis, or reverse diffusion. The two main types of proteins involved...
transmembrane pump, transporter, escort protein, acid transport protein, cation transport protein, or anion transport protein) is a protein that serves...
driven by ATP, that is, by metabolic energy, or as channels of facilitateddiffusion. A physiological process can only take place if it complies with...
membrane proteins that facilitate the transport of glucose across the plasma membrane, a process known as facilitateddiffusion. Because glucose is a vital...
Sequence homology with proteins belonging to the ubiquitous cationdiffusionfacilitator (CDF) family and the "Htr-like" serine proteases has been found...
hydrogen cation has different names: Hydron: general name referring to the positive ion of any hydrogen isotope (H+) Proton: 1H+ (i.e. the cation of protium)...
Sanders, Dale (15 May 2007). "A secretory pathway-localized cationdiffusionfacilitator confers plant manganese tolerance". Proceedings of the National...
attract and release cations in what is referred to as cation exchange. Cation-exchange capacity is the amount of exchangeable cations per unit weight of...
proteins embedded in it. The membrane serves as both an insulator and a diffusion barrier to the movement of ions. Transmembrane proteins, also known as...
uranium as fuel). There are two commercial enrichment processes: gaseous diffusion and gas centrifugation. Both enrichment processes involve the use of uranium...
between liver and blood Unlike GLUT4, it does not rely on insulin for facilitateddiffusion. In humans, this protein is encoded by the SLC2A2 gene. GLUT2 is...
molecules, ions, or other substances) across a cell membrane. It uses facilitateddiffusion for the movement of solutes down their concentration gradient from...
ammonium cation. It has the chemical formula [Me4N]+ and consists of four methyl groups (−CH3, denoted Me) attached to a central nitrogen atom. The cation is...
transporters can also function to move molecules through facilitateddiffusion. Facilitateddiffusion does not require ATP and allows molecules, that are unable...
blood–brain barrier via a proton-coupled organic cation antiporter and (to a lesser extent) via passive diffusion across cell membranes. Cocaine blocks the dopamine...
selectively permeable, with the passage of molecules controlled by facilitateddiffusion, passive transport or active transport regulated by proteins embedded...
cloned and mapped in 1989. At the cell surface, GLUT4 permits the facilitateddiffusion of circulating glucose down its concentration gradient into muscle...
which requires an accompanying cation. These cations are hydrated during the formation of the materials. The hydrated cations interrupt the otherwise dense...
Leaist DG, Lyons PA (1981). "Multicomponent diffusion of electrolytes with incomplete dissociation. Diffusion in a buffer solution". The Journal of Physical...
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