Carl Ulrich Franz Mannich (8 March 1877 in Breslau – 5 March 1947 in Karlsruhe) was a German chemist. From 1927 to 1943 he was professor for pharmaceutical chemistry at the University of Berlin. His areas of expertise were keto bases, alcohol bases, derivatives of piperidine, papaverine, lactones and also Digitalis-glycosides.
The Mannich reaction was named after his discovery of the mechanism in 1912.[1]
^Mannich, C.; Krösche, W. (1912). "Ueber ein Kondensationsprodukt aus Formaldehyd, Ammoniak und Antipyrin". Archiv der Pharmazie. 250: 647–667. doi:10.1002/ardp.19122500151. S2CID 94217627.
form between amines and aldehydes. The reaction is named after CarlMannich. The Mannich reaction starts with the nucleophilic addition of an amine to...
Carl Ulrich Franz Mannich (8 March 1877 in Breslau – 5 March 1947 in Karlsruhe) was a German chemist. From 1927 to 1943 he was professor for pharmaceutical...
of dopamine. Hydrocodone was first synthesized in Germany in 1920 by CarlMannich and Helene Löwenheim. It was approved by the Food and Drug Administration...
The ketimine Mannich reaction is an asymmetric synthetic technique using differences in starting material to push a Mannich reaction to create an enantiomeric...
University of Frankfurt in 1916. In 1920, hydrocodone was prepared by CarlMannich and Helene Löwenheim, deriving it from codeine. In 1924, hydromorphone...
Wilhelm Lossen Carl Jacob Löwig Georg Lunge Paul Luther Hermann Lux Heinrich Gustav Magnus Joachim Maier Christoph Mangold CarlMannich Richard Felix Marchand...
analgesic closely related to codeine, is first synthesized in Germany, by CarlMannich and Helene Löwenheim. Approximate date – The HIV/AIDS pandemic almost...
University of Frankfurt 1920–1924: First synthesis of hydrocodone by CarlMannich and Helene Löwenheim in 1920, first marketed by former German drug development...
analgesic closely related to codeine, is first synthesized in Germany by CarlMannich and Helene Löwenheim. Black Cross Nurses founded in the United States...
Schleswig-Holstein. For his life's achievements, he was awarded the CarlMannich Medal in 2016, the highest award of the German Pharmaceutical Society...
various classes of alkaloids, including synthesis of Schiff bases and Mannich reaction. Schiff bases can be obtained by reacting amines with ketones...
ligands. The first bispidine-based ligands dates back to 1930, when CarlMannich reported the synthesis of two different substituted bispidine molecules...
efficient synthesis of allylic amines with a modified Mannich reaction. In this modified Mannich reaction, they have found that vinyl boronic acids can...
reaction. Subsequently, he developed the first proline-catalyzed Mannich, Michael, and α-amination reactions. He found asymmetric catalysis (especially...
yielded. The indole is oxidized and the molecule undergoes intramolecular Mannich reaction and Grob fragmentation to form preakuammicine. Preakuammicine...
acetyl-CoA units to the N-methyl-Δ1-pyrrolinium cation. The first addition is a Mannich-like reaction with the enolate anion from acetyl-CoA acting as a nucleophile...
the presence of phosphoric acid as a catalyst. Under conditions for a Mannich reaction, ferrocene gives N,N-dimethylaminomethylferrocene. Ferrocene itself...
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