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Carbonyldiimidazole information


Carbonyldiimidazole
Names
Preferred IUPAC name
Di(1H-imidazol-1-yl)methanone
Other names
N,N'-carbonyldiimidazole
CDI
Staab reagent
Identifiers
CAS Number
  • 530-62-1 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 61561 checkY
ECHA InfoCard 100.007.718 Edit this at Wikidata
EC Number
  • 208-488-9
PubChem CID
  • 68263
UNII
  • 63A10X1FSP
CompTox Dashboard (EPA)
  • DTXSID9038761 Edit this at Wikidata
InChI
  • InChI=1S/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H checkY
    Key: PFKFTWBEEFSNDU-UHFFFAOYSA-N checkY
  • InChI=1/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H
    Key: PFKFTWBEEFSNDU-UHFFFAOYAX
SMILES
  • O=C(n1cncc1)n2ccnc2
Properties
Chemical formula
C7H6N4O
Molar mass 162.152 g·mol−1
Appearance White fine powder
Melting point 119 °C (246 °F; 392 K)
Solubility in water
Reacts with water
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Corrosive to some metals, Causes serious chemical burns upon skin or eye contact.
GHS labelling:
Pictograms
GHS05: CorrosiveGHS07: Exclamation mark
Signal word
Danger
Hazard statements
H302, H314, H315, H319
Precautionary statements
P260, P264, P270, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P332+P313, P337+P313, P362, P363, P405, P501
Safety data sheet (SDS) External MSDS
Related compounds
Related compounds
phosgene, imidazole
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

1,1'-Carbonyldiimidazole (CDI) is an organic compound with the molecular formula (C3H3N2)2CO. It is a white crystalline solid. It is often used for the coupling of amino acids for peptide synthesis and as a reagent in organic synthesis.

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Carbonyldiimidazole

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1,1'-Carbonyldiimidazole (CDI) is an organic compound with the molecular formula (C3H3N2)2CO. It is a white crystalline solid. It is often used for the...

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Thiocarbonyldiimidazole

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imidazole rings. It is the sulfur analog of the peptide coupling reagent carbonyldiimidazole (CDI). TCDI is commercially available but can also be prepared via...

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Benzimidazolinone

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carbonylation of 1,2-diaminobenzene. The carbonylation can be effected with carbonyldiimidazole. Like other ureas, it engages in hydrogen bonding, yielding supramolecular...

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Polyester

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chlorides, so-called activating agents can be used, such as 1,1'-carbonyldiimidazole, dicyclohexylcarbodiimide, or trifluoroacetic anhydride. The polycondensation...

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Diphosgene

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diphosgene is similar in hazard to phosgene. Phosgene Triphosgene Carbonyldiimidazole Keisuke Kurita and Yoshio Iwakura (1979). "Trichloromethyl Chloroformate...

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Thalidomide

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N-phthaloyl-L-glutamine (2). Cyclization of N-phthaloyl-L-glutamine occurs using carbonyldiimidazole, which then yields thalidomide (3). Celgene Corporation's original...

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DEA list of chemicals

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1-(4-methylphenyl)propan-1-one substituted cathinones and substituted amphetamines Carbonyldiimidazole LSD 1,1-Dichloro-1-fluoroethane solvent N-benzyl-4-piperidone fentanyl...

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Phosgene

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carbonyl group. For this purpose, alternatives to phosgene such as carbonyldiimidazole (CDI) are safer, albeit expensive. CDI itself is prepared by reacting...

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List of reagents

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consequently, it has been largely superseded by deuterated solvents Carbonyldiimidazole often used for the coupling of amino acids for peptide synthesis...

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CDI

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Depositary Interest, in investing, a form of depositary receipt in the UK Carbonyldiimidazole, an activating agent used for example for peptide coupling Central...

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Phosphorimidazolide

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using fewer reagents, a phosphate mono-ester is dissolved in DMF and carbonyldiimidazole (CDI) is used to both remove an oxygen atom from the phosphate group...

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Adinazolam

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with phthalic anhydride. The solution is cooled and treated with carbonyldiimidazole. Then 7-chloro-2-hydrazineyl-5-phenyl-3H-benzo[e][1,4]diazepine is...

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Cereblon E3 ligase modulator

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50–70% yield. The substance 4 is then stirred in a mixture with carbonyldiimidazole (CDI) with enough 4-dimethylaminopyridine (DMAP) in tetrahydrofuran...

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Debromoaplysiatoxin

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(DCC), N-chlorosuccinimide (NCS), sodium chlorite and 1,1'-carbonyldiimidazole (CDI). With 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) treatment...

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