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Phosphorimidazolide information


General chemical structure of a phosphorimidazolide reagent

A phosphorimidazolide is a chemical compound in which a phosphoryl mono-ester is covalently bound to a nitrogen atom in an imidazole ring. They are a type of phosphoramidate. These phosphorus (V) compounds are encountered as reagents used for making new phosphoanhydride bonds with phosphate mono-esters, and as reactive intermediates in phosphoryl transfer reactions in some enzyme-catalyzed transformations. They are also being studied as critical chemical intermediates for the polymerization of nucleotides in pre-biotic settings.[1] They are sometimes referred to as phosphorimidazolidates, imidazole-activated phosphoryl groups, and P-imidazolides.

  1. ^ Walton, Travis; Zhang, Wen; Li, Li; Pong Tam, Chun; Szostak, Jack (2019). "The Mechanism of Nonenzymatic Template Copying with Imidazole-Activated Nucleotides". Angewandte Chemie International Edition. 58 (32): 10812–10819. doi:10.1002/anie.201902050. PMID 30908802.

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Phosphorimidazolide

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A phosphorimidazolide is a chemical compound in which a phosphoryl mono-ester is covalently bound to a nitrogen atom in an imidazole ring. They are a...

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Leslie Orgel

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to polymerise and replicate. Lohrmann and Orgel reported that the phosphorimidazolide derivative of adenosine monophosphate (in which a phosphoryl group...

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