The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides.[1][2] The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity.[3]
Calpohostin
R1
R2
Calphostin A
Bz
Bz
Calphostin B
Bz
H
Calphostin C
Bz
4-(HO)Bz
Calphostin D
H
H
Calphostin I
4-(HO)Bz
4-(HO)Bz
^Kobayashi, E; Ando, K; Nakano, H; Iida, T; Ohno, H; Morimoto, M; Tamaoki, T (1989). "Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities". J. Antibiot. 42 (10): 1470–1474. doi:10.7164/antibiotics.42.1470. PMID 2478514.
^Iida, T; Kobayashi, E; Yoshida, M; Sano, H (1989). "Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures". J. Antibiot. 42 (10): 1475–1481. doi:10.7164/antibiotics.42.1475. PMID 2478515.
^Calphostin C (UCN-1028C)[permanent dead link] at Biomol
The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase...
Calphostin C is a natural chemical compound. It is one of the calphostins, isolated from the fungus Cladosporium cladosporioides. Calphostin C is a potent...
example of this being used is in the synthesis of the natural product Calphostin A, as seen below. Methyl esters also are susceptible to demethylation...
trees. This species also produces calphostins A, B, C, D and I, which are protein kinase C inhibitors. These calphostins have cytotoxic activity due to their...
Alpha-synuclein, Amphiphysin, BIN1, CDC42, PEA15, Protein kinase N1 RALA, and RHOA. Calphostin-c, an inhibitor VU-0359595: 1,700-fold selective versus phospholipase...