In molecular biology, the cadherin cytoplasmic region is a conserved region found at the C-terminus of cadherin proteins. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region (the part of the cytoplasmic region which is adjacent to the transmembrane domain) of the cadherin. This region induces clustering and also binds to the protein catenin (p120ctn).[1] The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton.[2]
^Yap AS, Niessen CM, Gumbiner BM (May 1998). "The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn". J. Cell Biol. 141 (3): 779–89. doi:10.1083/jcb.141.3.779. PMC 2132752. PMID 9566976.
^Nagafuchi A, Takeichi M (December 1988). "Cell binding function of E-cadherin is regulated by the cytoplasmic domain". EMBO J. 7 (12): 3679–84. doi:10.1002/j.1460-2075.1988.tb03249.x. PMC 454940. PMID 3061804.
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In molecular biology, the cadherincytoplasmicregion is a conserved region found at the C-terminus of cadherin proteins. A key determinant to the strength...
the juxtamembrane region of the cadherin. γ-catenin or gamma-catenin (plakoglobin) binds the catenin-binding region of the cadherin. α-catenin or alpha-catenin...
extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmicregion. These...
signal peptide, 27 cadherin repeat domains and a unique cytoplasmicregion. This particular cadherin family member is expressed in fibroblasts but not in...
extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought...
M (July 1999). "p120(ctn) binds to the membrane-proximal region of the E-cadherincytoplasmic domain and is involved in modulation of adhesion activity"...
cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic...
composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in...
N-terminal exons each encode six cadherin ectodomains, while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins...
glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts...
controlled and stable environment. As synapses mature in the CA3 region, nectins and cadherins, which affiliate closely with one another in synaptic stabilization...
cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic...
extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmicregion. These...
product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. This gene...
extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmicregion. These...
Plakoglobin forms distinct complexes with cadherins and desmosomal cadherins. Plakoglobin is a major cytoplasmic component of both desmosomes and adherens...
the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail...
extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmicregion. These...
extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. GRCh38:...
proteins that associate with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked...
cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic...
pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains...
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