CST11 information

CST11
Identifiers
Aliases	CST11, CST8L, CTES2, SC13, dJ322G13.6, cystatin 11
External IDs	OMIM: 609731; MGI: 1925490; HomoloGene: 15634; GeneCards: CST11; OMA:CST11 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	23,452,876 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	148,613,417 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; gonad; ; buccal mucosa cell; ; caput epididymis; ; tail of epididymis; ; decidua; ; stromal cell of endometrium; ; granulocyte; ; mucosa of nose; ; fundus;
	Top expressed in
	embryo; ; morula; ; dorsal striatum; ; white adipose tissue; ; foregut; ; gonad; ; stomach; ; testicle; ; gastrula;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity; protease binding; cysteine-type endopeptidase inhibitor activity;
Cellular component	sperm flagellum; sperm head; extracellular space; extracellular region; nucleus; cytoplasm;
Biological process	negative regulation of peptidase activity; defense response to bacterium; androgen receptor signaling pathway; defense response to Gram-negative bacterium; negative regulation of cysteine-type endopeptidase activity; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	140880
	78240
	ENSG00000125831
	ENSMUSG00000036958
	Q9H112
	Q9D269
	NM_130794; NM_080830
	NM_030059
	NP_543020; NP_570612
	NP_084335
	Wikidata
View/Edit Human	View/Edit Mouse

Cystatin-11 is a protein that in humans is encoded by the CST11 gene.^[5]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity.

There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions.

The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein whose specific function has not been determined. Alternative splicing yields two variants encoding distinct isoforms.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125831 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036958 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CST11 cystatin 11".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125831 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036958 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CST11 cystatin 11".

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